Results 81 to 90 of about 2,775,940 (306)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

High-impedance faulty feeder detection for cross-country faults in distribution networks based on zero-sequence active power regulation

International Journal of Electrical Power & Energy Systems
The weak characteristics of high-impedance faults and the complex attributes of cross-country faults make faulty feeder detection of cross-country high-impedance faults difficult in medium-voltage networks. This paper deduces the zero-sequence equivalent
Yuting Lan, Kun Yu, Xiangjun Zeng, Rong Cai, Qingbo Deng, Chenyu Wu, Shigeng He, Shijie Xu, Youcheng Jia   +8 more
doaj   +1 more source

Towards real-time monitoring of fear in driving sessions

, 2019
Recent statistical analysis on road transport report that human behaviour represents one of the main causes in road traffic accidents. In this context, the application of new technologies to monitor driver's conditions becomes essential to detect ...
Bersani, C, Zero, L, Sacile, R, Zero, E
core   +1 more source

Zero competence acquisition mechanisms and the influence of primary language impairment: single-case study [PDF]

, 2022
openNell'elaborato si affrontano i meccanismi di acquisizione del numero zero nello sviluppo tipico e atipico. Le prime evidenze in letteratura hanno suggerito un ruolo preponderante dell’abilità di calcolo nell’acquisizione del numero zero.
BORRECA, SARA
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Zeros of linear recurrence sequences [PDF]

manuscripta mathematica, 1999
Let \(f(x)= P_0(x) \alpha_0^x+\cdots+ P_k(x) \alpha_k^x\) be an exponential polynomial over a field \(\mathbb{K}\) of zero characteristic. For \(i=0,\dots, k\), \(0\neq P_i\in \mathbb{K}[x]\) and \(0\neq \alpha_i\in \mathbb{K}\) such that for each pair \((i,j)\) with \(i\neq j\), \(\alpha_i/ \alpha_j\) is not a root of unity.
Schlickewei, Hans Peter, Schmidt, Wolfgang M., Waldschmidt, Michel   +2 more
openaire   +2 more sources

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

On Subsequence Sums of a Zero-sum Free Sequence [PDF]

The Electronic Journal of Combinatorics, 2007
Let $G$ be a finite abelian group with exponent $m$, and let $S$ be a sequence of elements in $G$. Let $f(S)$ denote the number of elements in $G$ which can be expressed as the sum over a nonempty subsequence of $S$. In this paper, we show that, if $|S|=m$ and $S$ contains no nonempty subsequence with zero sum, then $f(S)\geq 2m-1$.
openaire   +2 more sources

On the zeros of linear recurrence sequences [PDF]

Acta Arithmetica, 2011
We improve by one exponential W. M. Schmidt's estimate for the Skolem-Mahler-Lech theorem on the number of arithmetic progressions describing the zeros of a linear recurrence sequence.
Amoroso, Francesco, Viada, Evelina
openaire   +4 more sources