Results 141 to 150 of about 128,863 (254)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

open access: yesAdvanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang   +10 more
wiley   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

open access: yesAdvanced Science, Volume 13, Issue 20, 9 April 2026.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui   +3 more
wiley   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

open access: yesAdvanced Science, Volume 13, Issue 20, 9 April 2026.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao   +5 more
wiley   +1 more source

Dengue, chikungunya, Virus de Zika. Determinantes sociales

open access: yesRevista Médica Electrónica
RESUMEN El dengue, chikungunya y zika son enfermedades del grupo de las arbovirosis, transmitidas por los mosquitos Aedes aegypti y Aedes albopictus.
María del Carmen Álvarez Escobar   +4 more
doaj  

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

open access: yesAdvanced Intelligent Discovery, Volume 2, Issue 2, April 2026.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki   +3 more
wiley   +1 more source

Fully Synthetic Non‐Carbohydrate Heparin Mimetics—Perspectives for Therapeutic Anticoagulation and Beyond?

open access: yesArchiv der Pharmazie, Volume 359, Issue 4, April 2026.
Fully synthetic sulfated non‐carbohydrate polymers for structurally mimicking the polysaccharide glycosaminoglycan heparin in its anticoagulant activities with further prospects to pleiotropic effects in oncology and in antiviral approaches. ABSTRACT Heparin is one of the oldest drugs on the market.
Katrin Nekipelov   +2 more
wiley   +1 more source

Zika Virus Infection Zika Virüs Enfeksiyonu

open access: yes, 2020
Zika virüsü, Flaviviridae familyasından, Flavivirüs genusundan zarflı, ikozahedral kapsid yapısında, tek zincirli bir RNA virüsüdür. Zika virüsü, 1947’de ilk kez izole edildiği bir Uganda ormanının adını almıştır. İlk olarak dünyada 2007’de Mikronezya Yap Adaları’nda, Batı yarımkürede 2014’te Şili’de ve ABD’de 2016’da tespit edilmiştir. Ülkemizdeki ilk
Barkay, Orçun, Karakeçili, Faruk
openaire   +1 more source

Interpopulation Variation in Egg Mortality in Response to Hot and Dry Conditions in North American Populations of the Invasive Tiger Mosquito, Aedes albopictus

open access: yesEcology and Evolution, Volume 16, Issue 4, April 2026.
North American populations of the invasive tiger mosquito exhibit genetic and phenotypic differences in egg survival in response to hot and dry conditions. ABSTRACT How wild organisms are responding to climate change is one of the most pressing issues of the 21st century.
Katie M. Westby   +4 more
wiley   +1 more source

Spherical Nucleic Acid Stabilized Cage Type Three‐Dimensional Electrochemiluminescence Probe for Sensitive and Amplification‐Free Diagnosis of Infectious Diseases

open access: yesExploration, Volume 6, Issue 2, April 2026.
This work developed a spherical nucleic acid stabilized cage‐type 3D electrochemiluminescence reporter probe for amplification‐free and ultrasensitive detection of pathogenic. Furthermore, a hand‐held detection device was designed, and we established a straightforward workflow enabling sample to answer within 15 min.
Yu Fu   +11 more
wiley   +1 more source

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