Results 61 to 70 of about 57,469 (198)
Zika virus infection: emerging a new vector-borne disease
Zika virus is an arthropod-borne virus that belongs to the Flaviridae family. It causes Zika disease which is characterised by headache, fever, arthralgia, conjunctivitis, rash and recently it is found to be associated with microcephaly and Guillain ...
Ali Danburam, Sadika
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Abstract The Paris 2024 Olympic Games posed a unique challenge due to their scale, associated risks and the need for robust healthcare preparedness. This review outlines the forecasting and anticipatory measures taken by the Etablissement français du sang (EFS) to ensure a resilient blood supply chain throughout the event.
Jean‐Baptiste Thibert +9 more
wiley +1 more source
Three series of pyrazole ribonucleoside analogues were designed and synthesized. They were evaluated, along with some of their pronucleotides, for their antiviral activity against RNA viruses. Pyrazole ribonucleoside analogues were prepared via a linear approach starting with the reaction of D‐ribosylhydrazine with 1,3‐dicarbonyl or acrylonitrile ...
Anaïs Guillou +6 more
wiley +1 more source
Zika virus disease : from origin to outbreak /
Zika Virus provides an authoritative account of one of most fascinating viruses of the 21st century, covering all the main points. It includes coverage of clinical manifestations, such as fever and fatigue, but also delves into neurological ...
Qureshi, Adnan I.,editor.
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Toolkit for investigating possible local mosquito-borne transmission of Zika virus [PDF]
The Centers for Disease Control and Prevention (CDC) has developed this toolkit to provide resources for investigating possible local mosquito-borne Zika virus transmission.
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Case report: microcephaly associated with Zika virus infection, Colombia
Background: Recently there has been a large outbreak of Zika virus infections in Colombia, South America. The epidemic began in September 2015 and continued to April 2017, for the total number of Zika cases reported of 107,870.
Gerhke, Lee +9 more
core +1 more source
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč +8 more
wiley +1 more source
Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub‐Saharan Africa
ABSTRACT Introduction Congenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under‐5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub‐Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity ...
Emma Kalk +18 more
wiley +1 more source
The impacts of biological invasions
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock +42 more
wiley +1 more source
ProTides for Antiviral Activity Beyond Liver Cells
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
wiley +1 more source

