Results 41 to 50 of about 48,489 (171)

Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus

mBio, 2019
Zika virus is a mosquito-borne flavivirus which can cause severe disease in humans, including microcephaly and other congenital malformations in newborns and Guillain-Barré syndrome in adults. There are currently no approved prophylactics or therapeutics
Mark J. Bailey, Felix Broecker, James Duehr, Fortuna Arumemi, Florian Krammer, Peter Palese, Gene S. Tan   +6 more
doaj   +1 more source

Government as orchestrator: Ecosystem transformation at scale and speed

Strategic Management Journal, EarlyView.
Abstract Research Summary Grand challenges are ecosystem challenges: success depends on aligning a multilateral set of public and private sector actors whose interdependent contributions determine whether a mission is achieved. This study examines how government can orchestrate ecosystem alignment by leveraging distinctive capabilities to deliver ...
Ron Adner
wiley   +1 more source

Zika virus infection – a new epidemic threat

Pediatria i Medycyna Rodzinna, 2016
Zika virus, like dengue and yellow fever viruses, is an RNA virus of the Flaviviridae family. The virus is transmitted by Aedes mosquitoes. On February 1, 2016, the World Health Organization declared Zika virus a Public Health Emergency of International
Dominika Pomorska, Ernest Kuchar
doaj   +1 more source

Frayed Rope and Resilient Threads: Fijian Healthcare and the COVID‐19 Pandemic

Asia Pacific Viewpoint, EarlyView.
ABSTRACT In April 2021, Fiji faced international scrutiny due to ‘horrific’ hospital conditions, including staff and patients lacking food, non‐operational operating theatres, and critical shortages of beds, medicine, and equipment. After successfully avoiding a major outbreak in 2020, a sudden surge in COVID‐19 cases in 2021 overwhelmed the public ...
Sharon McLennan, Johanna Thomas‐Maude, Apisalome Movono, Akisi Ravono   +3 more
wiley   +1 more source

Public involvement in the Brazilian Cerebral Palsy Register: An exploratory, sequential, mixed‐methods study

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To describe the implementation of a public involvement strategy based on the UK Standards for Public Involvement in Research within the Brazilian Cerebral Palsy Register (BrCPR). Method We conducted a participatory, exploratory, sequential, mixed‐methods study.
Luana Cristina da Silva, Claire Kerr, Israt Jahan, Raphael Fagundes Figueira Pinho, Aline Lincoln Silveira, Nádia Badawi, Gulam Khandaker, Gabriela Lorençoni Pauletti, Egmar Longo, Mercedes Ruiz Brunner, Paula Silva de Carvalho Chagas, Hércules Ribeiro Leite   +11 more
wiley   +1 more source

Envolvimento público no Registro Brasileiro de Paralisia Cerebral: um estudo exploratório, sequencial, de métodos mistos

Developmental Medicine &Child Neurology, EarlyView.
Resumo Objetivo Descrever a implementação da estratégia de envolvimento do público baseada nas normas do Reino Unido para o envolvimento do público em pesquisa no Registro Brasileiro de Paralisia Cerebral (RB‐PC). Métodos Realizamos um estudo participativo, exploratório, sequencial, de métodos mistos.
Luana Cristina da Silva, Claire Kerr, Israt Jahan, Raphael Fagundes Figueira Pinho, Aline Lincoln Silveira, Nádia Badawi, Gulam Khandaker, Gabriela Lorençoni Pauletti, Egmar Longo, Mercedes Ruiz Brunner, Paula Silva de Carvalho Chagas, Hércules Ribeiro Leite   +11 more
wiley   +1 more source

Characterization of a Zika Virus Isolate from Colombia. [PDF]

PLoS Neglected Tropical Diseases, 2016
Zika virus (Flavivirus genus) is the first mosquito-borne virus known to cause high rates of microcephaly and abortion in humans. Typically, Zika virus causes a self-limiting, systemic illness; however, the current outbreak of Zika virus in the Americas ...
Anismrita Lahon, Ravi P Arya, Alexander R Kneubehl, Megan B Vogt, Natalie J M Dailey Garnes, Rebecca Rico-Hesse   +5 more
doaj   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Navigating the Zika panic [version 1; referees: 2 approved]

F1000Research, 2016
The epidemics of Ebola virus in West Africa and Zika virus in America highlight how viruses can explosively emerge into new territories. These epidemics also exposed how unprepared we are to handle infectious disease emergencies.
Nathan D. Grubaugh, Kristian G. Andersen
doaj   +1 more source

Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.

PLoS Neglected Tropical Diseases, 2020
BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa, Iris Medits, Judith H Aberle, Stephan W Aberle, Denise Haslwanter, Georgios Tsouchnikas, Silke Wölfel, Kristina L Huber, Elena Percivalle, Pascal Cherpillod, Melissa Thaler, Lena Roßbacher, Michael Kundi, Franz X Heinz, Karin Stiasny   +14 more
doaj   +1 more source