Results 51 to 60 of about 1,092,883 (242)

Cleft analysis of Zika virus non-structural protein 1

Asian Pacific Journal of Tropical Biomedicine, 2017
The non-structural protein 1 is an important molecule of the viruses in flavivirus group including to Zika virus. Recently, the NS1 of Zika virus was discovered.
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Projecting Month of Birth for At-Risk Infants after Zika Virus Disease Outbreaks

Emerging Infectious Diseases, 2016
The marked increase in infants born with microcephaly in Brazil after a 2015 outbreak of Zika virus (Zika virus) disease suggests an association between maternal Zika virus infection and congenital microcephaly.
Jennita Reefhuis, Suzanne M. Gilboa, Michael A. Johansson, Diana Valencia, Regina M. Simeone, Susan L. Hills, Kara Polen, Denise J. Jamieson, Lyle R. Petersen, Margaret A. Honein   +9 more
doaj   +1 more source

Zika: what we do and do not know based on the experiences of Brazil [PDF]

Epidemiology and Health, 2016
OBJECTIVES: Zika virus, which was first discovered in 1947, has become a global threat to human health as it is rapidly spreading through Latin America, the Caribbean, the US and Asia, after causing a large outbreak in the Northeast region of Brazil in ...
Cristina Possas
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Risk of Zika virus transmission by blood donations in Brazil

Hematology, Transfusion and Cell Therapy, 2018
Background: Zika, a disease caused by Zika virus infections, has recently emerged and caused outbreaks in many parts of the world. The clinical manifestations of Zika are usually mild, mostly presenting as an exanthematic febrile disease, but on some ...
Mariana Munari Magnus, Danillo Lucas Alves Espósito, Victor Antonio da Costa, Priscila Silva de Melo, Carolina Costa-Lima, Benedito Antonio Lopes da Fonseca, Marcelo Addas-Carvalho   +6 more
doaj   +1 more source

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.

PLoS ONE, 2020
Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain
Rosemary J Steinbach, Nicole N Haese, Jessica L Smith, Lois M A Colgin, Rhonda P MacAllister, Justin M Greene, Christopher J Parkins, J Beth Kempton, Edward Porsov, Xiaojie Wang, Lauren M Renner, Trevor J McGill, Brandy L Dozier, Craig N Kreklywich, Takeshi F Andoh, Marjorie R Grafe, Heidi L Pecoraro, Travis Hodge, Robert M Friedman, Lisa A Houser, Terry K Morgan, Peter Stenzel, Jonathan R Lindner, Robert L Schelonka, Jonah B Sacha, Victoria H J Roberts, Martha Neuringer, John V Brigande, Christopher D Kroenke, Antonio E Frias, Anne D Lewis, Meredith A Kelleher, Alec J Hirsch, Daniel Neal Streblow   +33 more
doaj   +1 more source

Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

VIEW, EarlyView.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu, Ruping Liu, Na Gao, Jianxiao Zhu, Haowen Jiang, Shouzheng Jiao, Zhicheng Sun, Kai Shen, Gaolian Xu, Minghua Du, Ziyan Li, Yang Wang   +11 more
wiley   +1 more source

Spillover dynamics and asynchronous temporal fluctuations in host density and competence drive fungal parasite persistence in multi‐host, seasonal communities

Journal of Animal Ecology, EarlyView.
In this study, the authors develop a new model to show that species contributions to parasite persistence can have strong, asynchronous temporal variability, often limiting the effectiveness of targeted seasonal parasite control. The model is broadly applicable for partitioning who, when, and what drive parasite persistence in multi‐host seasonal ...
Sarah A. R. Schrock, Joseph A. DeMarchi, Billy J. Gardner, Matthew J. Gray, Michel E. B. Ohmer, Mark Q. Wilber   +5 more
wiley   +1 more source