Retinal Toxicity of Intravitreal Injection of Ziv-Aflibercept in Albino Rabbits. [PDF]
Transl Vis Sci Technol, 2018 To evaluate retinal toxicity of ziv-aflibercept, a drug that had been approved for use for patients with colon cancer.Twenty-two albino rabbits were injected intravitreally with 0.1 mL of ziv-aflibercept solution into the experimental eye and 0.1-mL saline into the control eye. Twelve were used for electroretinogram (ERG) at 4-weeks follow-up.
Ramon D +5 more
europepmc +5 more sources
Regression in polypoidal choroidal vasculopathy treated with ziv-aflibercept monotherapy - short term study. [PDF]
Saudi J Ophthalmol, 2021 PURPOSE: The aim of this study was to evaluate the effectiveness of intravitreal ziv-aflibercept (IVZ) in the treatment of polypoidal choroidal vasculopathy (PCV) and its efficacy in regard to polyp regression using optical coherence tomography (OCT) and indocyanine green angiography (ICGA ...
Mishra SB +6 more
europepmc +5 more sources
Intraperitoneal ziv-aflibercept effectively manages refractory ascites in colorectal cancer patients. [PDF]
Oncotarget, 2017 Ascites related to metastatic colorectal cancer (mCRC) reduces patient survival and quality of life, and systemic chemotherapy is largely ineffective for managing ascites. Here, we examined the clinical efficacy of intraperitoneal (IP) ziv-aflibercept for managing refractory ascites in 15 mCRC patients who did not respond to standard chemotherapy ...
Lu CS +11 more
europepmc +6 more sources
Osteonecrosis of the jaw associated with ziv-aflibercept [PDF]
Journal of Gastrointestinal Oncology, 2016 Medication-related osteonecrosis of the jaw (MRONJ) has been associated with medications that include bisphosphonates (BPs), denosumab, bevacizumab and sunitinib. Ziv-aflibercept is a recombinant human vascular endothelial growth factor (VEGF) receptor which has been used to treat patients with various advanced solid tumors.
Hani Mawardi +2 more
exaly +5 more sources
Retinal pigment epithelium rip following single intravitreal ziv-aflibercept injection
Indian Journal of Ophthalmology, 2018 Sumit Randhir Singh, Jay Chhablani
doaj +4 more sources
Fusion proteins for treatment of retinal diseases: aflibercept, ziv-aflibercept, and conbercept. [PDF]
Int J Retina Vitreous, 2016 In the last few years, monoclonal antibodies have revolutionized the treatment of retinal neovascular diseases. More recently, a different class of drugs, fusion proteins, has provided an alternative treatment strategy with pharmacological differences.
de Oliveira Dias JR +4 more
europepmc +5 more sources
Evaluation of aflibercept and ziv-aflibercept binding affinity to vascular endothelial growth factor, stability and sterility after compounding [PDF]
International Journal of Retina and Vitreous, 2018 Purpose To investigate the binding affinity, stability, and sterility of aflibercept and ziv-aflibercept to vascular endothelial growth factor (Holash et al. in Proc Natl Acad Sci USA 99(17):11393–11398, 2002.
Julia de Lima Farah +11 more
doaj +2 more sources
Intravitreal injection of ziv-aflibercept in the treatment of choroidal and retinal vascular diseases [PDF]
Journal of Current Ophthalmology, 2017 Purpose: To investigate the short-term outcomes after intravitreal injection of ziv-aflibercept in the treatment of choroidal and retinal vascular diseases.
Kamran HodjatJalali +5 more
doaj +2 more sources
Viability of Primary Human Pigment Epithelium Cells and Muller-Glia Cells after Intravitreal Ziv-Aflibercept and Aflibercept [PDF]
, 2016 Purpose: The aim of this study was to access the safety profiles of 2 fusion proteins with anti-vascular endothelial growth factor action (ziv-aflibercept and aflibercept) on retinal pigment epithelium cells and Muller-Glia cells in culture by assessing ...
Gabriel Costa de Andrade +7 more
openalex +4 more sources