Results 61 to 70 of about 861 (122)

Antiangiogenic and Antitumor Activities of Aflibercept, a Soluble VEGF Receptor-1 and -2, in a Mouse Model of Hepatocellular Carcinoma

Neoplasia: An International Journal for Oncology Research, 2016
BACKGROUND & AIM: Aflibercept known as ziv-aflibercept in the United States is a soluble decoy receptor of both vascular endothelial growth factor (VEGF) receptor-1 and -2 known to inhibit the binding of VEGF and placental growth factor (PlGF) to VEGF ...
Takuji Torimura, Hideki Iwamoto, Toru Nakamura, Mitsuhiko Abe, Yu Ikezono, Fumitaka Wada, Takahiko Sakaue, Hiroshi Masuda, Osamu Hashimoto, Hironori Koga, Takato Ueno, Hirohisa Yano   +11 more
doaj   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 591-605, October 2024.
Fisetin has been shown to exhibit significant impact on colorectal cancer (CRC) in animal models by targeting various cellular and molecular mechanisms. It inhibits the phosphorylation of Y‐box binding protein 1 and ribosomal S6 kinase and promotes the phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK1/2), thereby disrupting the repair ...
Mohammad Yasin Zamanian, Niloofar Taheri, Montather F. Ramadan, Yasser Fakri Mustafa, Safa Alkhayyat, Klunko Nataliya Sergeevna, Hashem O. Alsaab, Ahmed Hjazi, Farnoosh Molavi Vasei, Siamak Daneshvar   +9 more
wiley   +1 more source

Autofluorescence indexes as biomarkers for antiangiogenic loading dose outcome in diabetic macular edema

Therapeutic Advances in Ophthalmology, 2020
Purpose: To evaluate the combination of fundus autofluorescence results with several clinical and structural variables into mathematical indexes to enhance their ability to predict visual and anatomical changes after the antivascular endothelial growth ...
Sergio E. Hernández Da Mota, Francisco Béjar Cornejo, Marcela Esquivel Velázquez, Virgilio Lima Gómez, Gerardo González Saldívar, Ernesto Rodríguez Ayala, Raul Vélez-Montoya   +6 more
doaj   +1 more source

Angiogenesis Inhibitors in Small Cell Lung Cancer

Frontiers in Oncology, 2021
Inhibition of angiogenesis has been demonstrated to be an efficacious strategy in treating several tumors. Vascular endothelial growth factor (VEGF) is the most important protein with proangiogenic functions and it is overexpressed in small cell lung ...
Agnese Montanino, Anna Manzo, Guido Carillio, Giuliano Palumbo, Giovanna Esposito, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Gerardo Botti, Maria C. Piccirillo, Priscilla Cascetta, Giacomo Pascarella, Carmine La Manna, Nicola Normanno, Alessandro Morabito   +14 more
doaj   +1 more source

Enhancing cancer immunotherapy and antiangiogenic therapy by regulating gut microbes: Opportunities and challenges

MedComm – Oncology, Volume 3, Issue 3, September 2024.
Immune checkpoint therapy is the main means of cancer treatment. However, most patients develop strong resistance to it. Another cancer treatment is antiangiogenic therapy. It enhances tumor immune response. Gut microbes enhance the efficacy of immunotherapy. We hope that the three of them will be able to treat cancer together.
Jie Xu, Yaomei Tian, Die Hu, Xi Yan, Li Yang   +4 more
wiley   +1 more source

Systemic treatment for lung carcinoids: from bench to bedside

Clinical and Translational Medicine, Volume 8, Issue 1, December 2019., 2019
AbstractIn the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular alterations. Despite their indolent behavior, lung carcinoids correlate with a worse survival.
Mariangela Torniai, Laura Scortichini, Francesca Tronconi, Corrado Rubini, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti, Rossana Berardi   +7 more
wiley   +1 more source

Precision treatment in colorectal cancer: Now and the future

JGH Open, Volume 3, Issue 5, Page 361-369, October 2019., 2019
The approved epidermal growth factor receptor (EGFR)‐targeted and vascular endothelial growth factor (VEGF)‐targeted inhibitors suppress colorectal cancer cell invasion, proliferation and angiogenesis via Ras/Raf/MEK/ERK and PI3K/AKT signaling pathways.
Tung On Yau
wiley   +1 more source

Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy

Journal of Hematology & Oncology, 2012
The diverse pathways and molecules involved in angiogenesis, the formation of new blood vessels, have been targeted for the treatment of colorectal and other cancers.
Sun Weijing
doaj   +1 more source

Monitoring Dual VEGF Inhibition in Human Pancreatic Tumor Xenografts With Dynamic Contrast-Enhanced Ultrasound

Technology in Cancer Research & Treatment, 2020
Background: Association of drugs acting against different antiangiogenic mechanisms may increase therapeutic effect and reduce resistance. Noninvasive monitoring of changes in the antiangiogenic response of individual tumors could guide selection and ...
Michele Lamuraglia MD, PhD, Guillaume Barrois PhD, Delphine Le Guillou-Buffello PhD, Mathieu Santin PhD, Anne Kerbol MD, Eva Comperat MD, Alain Coron PhD, Olivier Lucidarme MD, PhD, S. Lori Bridal PhD   +8 more
doaj   +1 more source