Results 201 to 210 of about 91,984 (280)

Refining responsive antimicrobial nanomaterials from random peptide libraries via machine learning

Responsive Materials, EarlyView.
Machine learning refines random peptide mixtures into responsive antimicrobial cocktails, yielding enhanced antibacterial efficacy and improved in vivo therapeutic effects. Abstract Antimicrobial resistance has evolved into one of the most serious threats to global public health, yet generalizable routes for refining random peptide mixtures (RPMs) into
Lin Wang, Lexuan Shi, Bocheng Xu, Lutong Zhou, Tingjun Chen, Chen Yang, Mingliang Jin, Yizhen Wang   +7 more
wiley   +1 more source

Enhancing the Chemical Reactivity of Graphene through Substrate Engineering

Small, EarlyView.
This review highlights methods to enhance the reactivity of graphene through substrate engineering, focusing on strain and charge doping. Strains induced by nanoparticles, metal crystal orientations, or stretchable polymers increase the reactivity of graphene.
Jia Tu, Mingdi Yan
wiley   +1 more source

Triptolide decreases podocytes permeability by regulating TET2-mediated hydroxymethylation of ZO-1. [PDF]

Exp Biol Med (Maywood)
Tang YW, Jiang MY, Cao JW, Wan F.
europepmc   +1 more source

The interplay between occludin and ZO-1 is redox sensitive

, 2011
The blood-brain barrier is the interface between the blood and the central nervous system; one of its key elements is the brain capillary endothelium. The paracellular cleft between the brain capillary endothelial cells is sealed by the tight junctions (TJ), protein complexes that restrict the free diffusion of water and water soluble molecules across ...
openaire   +1 more source

A Selective Deposition Strategy of Ultrathin Metal Layer on Sub‐Micrometer‐Pitch Cu Interconnection for Low‐Temperature Hybrid Bonding

Small Science, EarlyView.
Conventional hybrid bonding approaches require high temperatures and long annealing times, limiting their compatibility with advanced semiconductor packaging. To overcome this limitation, various interfacial metals have been selected to enable uniform electroless deposition on sub‐micrometer Cu pads while preserving dielectric integrity, offering a low‐
Zambaga Otgonbayar, Jungchul Noh, Seong‐Ho Yoon, Gyu‐Sik Park, Suk Jekal, Jiwon Kim, Jeong‐Hwan Lee, Rino Choi, Jeonghun Kim, Myeongjin Kim, Chang‐Min Yoon   +10 more
wiley   +1 more source

TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner. [PDF]

Int J Biol Sci
Yang X, Shen X, Liu Z, Li Y, Liu H, Zhan Y, Liu Y, Liang C, Zhao L, Zhang X, Huang Y, Shen W.   +11 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border. [PDF]

Cell Commun Signal
Wang K, Qu H, Hu R, Lassègue B, Eaton DC, Song C, Mu J, Griendling KK, Hernandes MS.   +8 more
europepmc   +1 more source

A secured cloud‐medical data sharing with A‐BRSA and Salp ‐Ant Lion Optimisation Algorithm

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract Sharing medical data among healthcare providers, researchers, and patients is crucial for efficient healthcare services. Cloud‐assisted smart healthcare (s‐healthcare) systems have made it easier to store EHRs effectively. However, the traditional encryption algorithms used to secure this data can be vulnerable to attacks if the encryption key
Adel Binbusayyis, Abed Alanazi, Shtwai Alsubai, Areej Alasiry, Mehrez Marzougui, Abdullah Alqahtani, Mohemmed Sha, Muhammad Aslam   +7 more
wiley   +1 more source

Annexin A1 Mitigates Blood-Brain Barrier Disruption in a Sepsis-Associated Encephalopathy Model by Enhancing the Expression of Occludin and Zonula Occludens-1 (ZO-1). [PDF]

CNS Neurosci Ther
Li Y, Zhou F, You J, Gong X.
europepmc   +1 more source