Results 1 to 10 of about 19,753 (208)

Zoledronic acid and atorvastatin inhibit αvβ3-mediated adhesion of breast cancer cells

Journal of Bone Oncology, 2014
Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases.
Maria Wilke, Andy Göbel, Martina Rauner, Peggy Benad-Mehner, Norbert Schütze, Susanne Füssel, Peyman Hadji, Lorenz C. Hofbauer, Tilman D. Rachner   +8 more
doaj   +2 more sources

Treatment of osteoporosis with annual iv zoledronic acid: effects on hip fracture

Therapeutics and Clinical Risk Management, 2009
Roland D ChapurlatINSERM U831, Université de Lyon, Division of Rheumatology, Hôpital E Herriot, Hospices Civils de Lyon, Lyon, FranceBackground: Several treatments for postmenopausal osteoporosis have been available in the past ...
Rol, D Chapurlat
doaj   +1 more source

How zoledronic acid improves osteoporosis by acting on osteoclasts

Frontiers in Pharmacology, 2022
Osteoporosis is called a silent disease, because it is difficult to detect until comprehensive examinations for osteoporosis are performed or osteoporotic fractures occur.
Biao Wang, Yi Zhan, Yi Zhan, Liang Yan, Dingjun Hao   +4 more
doaj   +1 more source

Cost-Effectiveness of Sequential Denosumab/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China

Frontiers in Pharmacology, 2022
Objective: The primary purpose of this study was to estimate the cost-effectiveness of sequential denosumab/zoledronic acid versus zoledronic acid monotherapy for postmenopausal osteoporotic women in China.Methods: We updated and utilized a previously ...
Ruxu You, Jinyu Liu, Lei Ke, Min Wan, Yu Zhang, Guangyi Yu, Takahiro Mori, Takahiro Mori, Takahiro Mori   +8 more
doaj   +1 more source

Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells

Frontiers in Pharmacology, 2023
Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway.
Tianhao Ren, Ju Huang, Wei Sun, Guangze Wang, Yuwen Wu, Zewei Jiang, Yingshuai Lv, Guang Wu, Jiawei Cao, Min Liu, Haihua Gu   +10 more
doaj   +1 more source

Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source

Cost-Effectiveness of Sequential Teriparatide/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China

Frontiers in Public Health, 2022
ObjectiveWe aimed to assess the cost-effectiveness of sequential teriparatide/zoledronic acid relative to zoledronic acid monotherapy for postmenopausal osteoporotic women in China.MethodsA previously validated Markov microsimulation model was updated to
Ruxu You, Jinyu Liu, Lei Ke, Guangyi Yu, Yu Zhang, Takahiro Mori, Takahiro Mori, Takahiro Mori   +7 more
doaj   +1 more source

Investigation of Intravenous Zoledronic Acid Therapy on Circulating Lymphocyte Subpopulation in Patients with Primary Osteoporosis: A Pilot Study

Current Therapeutic Research, 2021
: Background: Several studies have investigated the immunomodulating properties of zoledronic acid on T lymphocytes, but the causal relationship between the function of T cells and the efficacy of zoledronic acid has not been elucidated Objective: To ...
Min Cui, Ph. D, Na Zhang, M.Med, Gang Zhang, B. Med, Lei Han, M.Med, Ling Zhi Yu, Ph. D   +4 more
doaj   +1 more source

Comparison of Denosumab and Zoledronic acid as neoadjuvant therapy in patients with giant cell tumor of bone

Journal of Orthopaedic Surgery, 2021
Objectives: Both Zoledronic acid and denosumab have been utilized in neo-adjuvant setting for facilitating surgery and downsizing the lesion in Giant cell tumor (GCT).
Himanshu Kanwat, Roshan Banjara, Venkatesan Sampath Kumar, Abdul Majeed, Shivanand Gamnagatti, Shah Alam Khan   +5 more
doaj   +1 more source

Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83. [PDF]

PLoS ONE, 2014
Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are
Xi-Yuan Ge, Lin-Qian Yang, Yang Jiang, Wen-Wen Yang, Jia Fu, Sheng-Lin Li   +5 more
doaj   +1 more source