Results 1 to 10 of about 5,138,607 (284)
Frontiers in Pharmacology, 2023 Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway.
Tianhao Ren +10 more
doaj +2 more sources
How zoledronic acid improves osteoporosis by acting on osteoclasts
Frontiers in Pharmacology, 2022 Osteoporosis is called a silent disease, because it is difficult to detect until comprehensive examinations for osteoporosis are performed or osteoporotic fractures occur.
Biao Wang +4 more
doaj +2 more sources
Journal of Orthopaedic Surgery, 2021 Objectives: Both Zoledronic acid and denosumab have been utilized in neo-adjuvant setting for facilitating surgery and downsizing the lesion in Giant cell tumor (GCT).
Himanshu Kanwat +5 more
doaj +2 more sources
Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving Gonadotropin-Releasing Hormone Analog [PDF]
Prostate Cancer, 2011 Background. Loss of bone density with androgen deprivation therapy for prostate cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone mineral density (BMD) and markers of bone turnover over a one-year period ...
Anoop Kapoor +3 more
doaj +3 more sources
Adrenal Crisis Induced by Zoledronic Acid in Two Patients With Hypopituitarism: A Case Report and Literature Review. [PDF]
Case Rep EndocrinolAdrenal insufficiency (AI) is characterized by inadequate steroid hormone production and is frequently a consequence of hypopituitarism, which is also associated with increased risk of osteoporosis due to deficiencies in growth hormone, gonadotropins, and other pituitary hormones.
AlFaifi AM, AlMistehi WM.
europepmc +2 more sources
Zoledronic Acid Is Not Equally Potent on Osteoclasts Generated From Different Individuals
JBMR Plus, 2020 Zoledronic acid is a bisphosphonate commonly used to treat bone diseases such as osteoporosis and cancer‐induced bone disease. Patients exhibit a variable sensitivity to zoledronic acid; the underlying explanation for this remains unclear.
Anaïs M J Møller +5 more
doaj +2 more sources
Synergistic effect of graphene oxide and zoledronic acid for osteoporosis and cancer treatment [PDF]
Scientific Reports, 2020 Zoledronic acid (ZOL) is a third generation bisphosphonate which can be used as a drug for the treatment of osteoporosis and metastasis. In this study, graphene oxide (GO) is conjugated with ZOL, and the nanostructured material is evaluated in terms ...
Gökçen Boran +4 more
semanticscholar +2 more sources
Effect of Zoledronic Acid on Skeletal Muscle After Bariatric Surgery: A Secondary Analysis From a Randomized Controlled Trial. [PDF]
Obesity (Silver Spring)ABSTRACT Objective This study aimed to investigate whether a single infusion of 5 mg zoledronic acid, given before bariatric surgery to prevent bone loss, could also hinder the loss of muscle mass, strength, and physical function. Methods In this double‐blinded study, patients referred for bariatric surgery were randomized 1:1 to either intervention ...
Gam S +4 more
europepmc +2 more sources
Frontiers in Pharmacology, 2020 ObjectiveThis study aims to estimate the cost-effectiveness of yearly intravenous zoledronic acid treatment versus weekly oral alendronate for postmenopausal osteoporotic women in China.MethodsWe used a Markov microsimulation model to compare the cost ...
Ruxu You +8 more
doaj +2 more sources
Prenylation inhibition-induced cell death in melanoma: reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells. [PDF]
PLoS ONE, 2015 While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we investigated the response to ...
Tamás Garay +13 more
doaj +5 more sources