Results 1 to 10 of about 5,898,256 (196)
Frontiers in Pharmacology, 2023 Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway.
Tianhao Ren +10 more
doaj +2 more sources
How zoledronic acid improves osteoporosis by acting on osteoclasts
Frontiers in Pharmacology, 2022 Osteoporosis is called a silent disease, because it is difficult to detect until comprehensive examinations for osteoporosis are performed or osteoporotic fractures occur.
Biao Wang +4 more
doaj +2 more sources
Journal of Orthopaedic Surgery, 2021 Objectives: Both Zoledronic acid and denosumab have been utilized in neo-adjuvant setting for facilitating surgery and downsizing the lesion in Giant cell tumor (GCT).
Himanshu Kanwat +5 more
doaj +2 more sources
Fanconi Syndrome After a Single Exposure to Intravenous Zoledronic Acid [PDF]
Clinical Case ReportsBisphosphonates are commonly used to reduce fracture risk in patients with osteoporosis, in those with malignant metastatic bone disease and for treatment of malignant hypercalcaemia.
Rita Deb +2 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Objective: The primary purpose of this study was to estimate the cost-effectiveness of sequential denosumab/zoledronic acid versus zoledronic acid monotherapy for postmenopausal osteoporotic women in China.Methods: We updated and utilized a previously ...
Ruxu You +8 more
doaj +1 more source
Frontiers in Public Health, 2022 ObjectiveWe aimed to assess the cost-effectiveness of sequential teriparatide/zoledronic acid relative to zoledronic acid monotherapy for postmenopausal osteoporotic women in China.MethodsA previously validated Markov microsimulation model was updated to
Ruxu You +7 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg +8 more
doaj +1 more source
Current Therapeutic Research, 2021 : Background: Several studies have investigated the immunomodulating properties of zoledronic acid on T lymphocytes, but the causal relationship between the function of T cells and the efficacy of zoledronic acid has not been elucidated Objective: To ...
Min Cui, Ph. D +4 more
doaj +1 more source
Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83. [PDF]
PLoS ONE, 2014 Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are
Xi-Yuan Ge +5 more
doaj +1 more source
Zoledronic acid inhibits the bone metastasis of breast cancer by repressing exosome-loaded DKK1
Bangladesh Journal of Pharmacology, 2022 This study is designed to investigate the mechanism underlying zoledronic acid for the bone metastasis of breast cancer. Dickkopf 1 (DKK1) was both expressed in breast cancer cells and exosomes isolated from breast cancer cells.
Bin Bin Song +4 more
doaj +1 more source