Results 11 to 20 of about 5,114,489 (264)

Prenylation inhibition-induced cell death in melanoma: reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells. [PDF]

PLoS ONE, 2015
While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we investigated the response to ...
Tamás Garay, István Kenessey, Eszter Molnár, Éva Juhász, Andrea Réti, Viktória László, Anita Rózsás, Judit Dobos, Balázs Döme, Walter Berger, Walter Klepetko, József Tóvári, József Tímár, Balázs Hegedűs   +13 more
doaj   +5 more sources

Treatment of osteoporosis with annual iv zoledronic acid: effects on hip fracture

Therapeutics and Clinical Risk Management, 2009
Roland D ChapurlatINSERM U831, Université de Lyon, Division of Rheumatology, Hôpital E Herriot, Hospices Civils de Lyon, Lyon, FranceBackground: Several treatments for postmenopausal osteoporosis have been available in the past ...
Rol, D Chapurlat
doaj   +1 more source

Osteoarthritis Flare-up Secondary to Zoledronic Acid Infusion: A Case Report [PDF]

Oman Medical Journal
Zoledronic acid is commonly used to treat osteoporosis and it is generally well tolerated. We describe the case of a woman with osteoporosis, who developed a flare-up of osteoarthritis hours after receiving a single dose of zoledronic acid. She developed
Maisa H. Al Kiyumi, Maryam Al Kiyumi, Amira Al Harrasi, Yaqoub Al Saidi, Hana Al Sumri, Asma Al Shidhani, Sanaa Al Sumri, Abdulaziz Al Mahrezi   +7 more
doaj   +2 more sources

Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

Journal of Experimental & Clinical Cancer Research, 2019
Background Zoledronic acid is the most potent osteoclast inhibitor and is widely used for advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) remains unclear.
Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang, Feng Luo   +7 more
doaj   +2 more sources

Effect of zoledronic acid therapy in an in vivo model of bone invasive feline oral squamous cell carcinoma [PDF]

, 2009
Professional Biological Sciences: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Objective: To test the hypothesis that zoledronic acid will inhibit tumor-induced osteolysis and reduce tumor growth and invasion in a ...
Chelsea K. Martin
openalex   +3 more sources

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Aging, 2023
In addition to reducing fracture risk, zoledronic acid has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals.
Parinya Samakkarnthai, D. Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, Graham G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, N. LeBrasseur, J. Farr, P. Robbins, S. Khosla   +18 more
semanticscholar   +1 more source

Cost-Effectiveness of Sequential Denosumab/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China

Frontiers in Pharmacology, 2022
Objective: The primary purpose of this study was to estimate the cost-effectiveness of sequential denosumab/zoledronic acid versus zoledronic acid monotherapy for postmenopausal osteoporotic women in China.Methods: We updated and utilized a previously ...
Ruxu You, Jinyu Liu, Lei Ke, Min Wan, Yu Zhang, Guangyi Yu, Takahiro Mori, Takahiro Mori, Takahiro Mori   +8 more
doaj   +1 more source

The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. [PDF]

, 2014
We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), and ...
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hassanein, Mohamed K, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Matsuyama, Ryusei, Menen, Rhiana, Miwa, Shinji, Momiyama, Masashi, Mori, Ryutaro, Murakami, Takashi, Tanaka, Kuniya, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya   +17 more
core   +9 more sources

Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source

Cost-Effectiveness of Sequential Teriparatide/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China

Frontiers in Public Health, 2022
ObjectiveWe aimed to assess the cost-effectiveness of sequential teriparatide/zoledronic acid relative to zoledronic acid monotherapy for postmenopausal osteoporotic women in China.MethodsA previously validated Markov microsimulation model was updated to
Ruxu You, Jinyu Liu, Lei Ke, Guangyi Yu, Yu Zhang, Takahiro Mori, Takahiro Mori, Takahiro Mori   +7 more
doaj   +1 more source