Results 31 to 40 of about 5,114,489 (264)
Medicina Oral, 2020 Background The aim of the present study was to analyse the incidence, risk ratio (RR) and prognoses of two types of medication-related osteonecrosis of the jaws (MRONJ): denosumab-related osteonecrosis of the jaws (DRONJ) and Bisphosphonate-Related ...
Álvaro Limones +5 more
semanticscholar +1 more source
Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients
Drug Design, Development and Therapy, 2021 Purpose Several osteoporosis drugs can continuously improve bone mass, but the impact on muscle mass is still unknown. This study aims to investigate how zoledronic acid monotherapy affected muscle mass in osteoporosis patients.
Chun-Feng Huang, M. Shiao, Tso-Yen Mao
semanticscholar +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
core +6 more sources
Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models. [PDF]
, 2015 Bone metastasis is a frequent occurrence in prostate cancer patients and often is lethal. Zoledronic acid (ZOL) is often used for bone metastasis with limited efficacy.
Bouvet, Michael +9 more
core +8 more sources
KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models [PDF]
, 2017 BACKGROUND: In non-small cell lung cancer (NSCLC) KRAS-mutant status is a negative prognostic and predictive factor. Nitrogen-containing bisphosphonates inhibit prenylation of small G-proteins (e.g.
Barone +44 more
core +1 more source
Journal of the American Medical Association (JAMA), 2020 Importance A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.
G. Cai +13 more
semanticscholar +1 more source
Zoledronic acid inhibits the bone metastasis of breast cancer by repressing exosome-loaded DKK1
Bangladesh Journal of Pharmacology, 2022 This study is designed to investigate the mechanism underlying zoledronic acid for the bone metastasis of breast cancer. Dickkopf 1 (DKK1) was both expressed in breast cancer cells and exosomes isolated from breast cancer cells.
Bin Bin Song +4 more
doaj +1 more source
Cost-utility of adjuvant zoledronic acid in patients with breast cancer and low estrogen levels [PDF]
, 2015 BACKGROUND: Adjuvant zoledronic acid (za) appears to improve disease-free survival (dfs) in women with early-stage breast cancer and low levels of estrogen (lle) because of induced or natural menopause.
Lamond, Nathan W D +3 more
core +1 more source
Cureus, 2021 Zoledronic acid is a bisphosphonate that has recently gained interest in adjuvant therapy for giant cell tumor of bone (GCTB). It has an apoptotic effect on osteoclasts that are precursors of GCTB.
Arvind Kumar +4 more
semanticscholar +1 more source
Dental journal, 2021 The aim of this systematic review is to present an up-to-date review of available publications investigating the cellular mechanisms initiating the development of medication-related osteonecrosis of the jaw caused by zoledronic acid.
Aya Alsalih +3 more
semanticscholar +1 more source