Results 31 to 40 of about 19,753 (208)

An in vivo assay for osteoclast activity using mouse calvaria

Animal Models and Experimental Medicine, EarlyView.
This study describes a novel method for measuring osteoclast‐mediated bone resorption in vivo using a mouse model. Localized injection of RANKL in a basement membrane matrix above the cranium induced osteoclast‐mediated bone resorption. Utilizing micro‐computed tomography and a semiautomated three‐dimensional analysis program, osteoclast resorption pit
Christopher Grieg, Maya Deza Culbertson, J. Patrick O'Connor   +2 more
wiley   +1 more source

Acute unilateral anterior uveitis following zoledronic acid infusion: A case report

SAGE Open Medical Case Reports, 2020
Bisphosphonates are widely used to treat several clinical conditions. Zoledronic acid is one of this class, commonly used for the treatment and prevention of osteoporosis, hypercalcemia of malignancy, Paget’s disease, and multiple myeloma.
Kiruththihan Anandasayanan, Muthusamy Malaravan, Navaneethakrishnan Suganthan   +2 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Lessons learned from long-term side effects after zoledronic acid infusion following denosumab treatment: a case report and review of the literature

Journal of Medical Case Reports, 2022
Background Zoledronic acid is an intravenous, highly potent aminobisphosphonate for use in patients with primary or secondary osteoporosis. Zoledronic acid-induced prolonged side-effects are well known and quite common.
Ilona Nurmi-Lüthje, Peter Lüthje
doaj   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Comprehensive evaluation of compound Kushen injection combined with zoledronic acid in treating bone metastasis cancer pain based on meta-analysis and decision tree model

Frontiers in Pain Research
ObjectiveTo evaluate the safety, efficacy, and cost-effectiveness of combining Compound Kushen Injection (CKI) with zoledronic acid in the treatment of bone metastasis-induced cancer pain in malignant tumors.MethodsA comprehensive search of Chinese and ...
Xi Zhao, Tianwei Meng, Kaiqiang Wang, Xi Yan, Yuqiang Liu, Xinghua Li   +5 more
doaj   +1 more source

Clinical practice guidelines for the diagnosis and treatment of osteoporosis secondary to ankylosing spondylitis

Rheumatology &Autoimmunity, EarlyView.
Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the axial skeleton and is often associated with secondary osteoporosis. Currently, there are no established international consensus or guidelines for managing AS‐related osteoporosis (AS‐OP). This guideline was jointly developed by several Chinese academic institutions,
Yasong Li, Liang Wang, Hongzhi Wang, Han Wang, Huaxiang Wu, Qifeng Ying, Dongbao Zhao, Lan He, Xuewu Zhang, Jian Zhu, Sanzhong Xu, Yi Yuan, Dun Hong, Peijian Tong, Ping Huang, Zhenchun Zhang, Hongwei Du, Yizhong Li, Xiaochun Zhu, Lijuan Wang, Zhangxuan Shou, Hao Zhang, Feng Huang, Weidong Xu   +23 more
wiley   +1 more source

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model

Journal of Orthopaedic Translation, 2021
Background: Osteonecrosis of the femoral head (ONFH) is a refractory disease due to its unclear pathomechanism. Neither conservative treatment nor surgical treatment during the early stage of ONFH achieves satisfactory results. Therefore, this study aims
Jun Zhao, Tian Yue, Shibi Lu, Haoye Meng, Qiuxia Lin, Haiyang Ma, Guangbo Liu, Huo Li, Qiang Lu, Aiyuan Wang, Wenjing Xu, Jing Feng, Yiqun Wan, Sida Liao, Xuefeng Zhou, Jiang Peng   +15 more
doaj   +1 more source

NIR‐Responsive Nano‐Integrated Magnesium Phosphate Cement Promotes Bone Regeneration via Osteoblast‐Exosome‐Osteoclast Crosstalk

Rare Metals, EarlyView.
ABSTRACT The limited osteogenic capacity of magnesium phosphate cement (MPC) has constrained its biomedical applications, underscoring the necessity to develop MPC with enhanced physical properties and bone‐forming capabilities. In this study, a multifunctional MPC system was developed by incorporating zoledronic acid‐loaded near‐infrared (NIR ...
Bin Wang, Shun‐Jie Wu, Xin‐Lin Lu, Yong Ge, Yue Zhang, Zhi‐Xiang Ma, Bin Xu, Paul‐K. Chu, Yan‐Bin Zhao   +8 more
wiley   +1 more source