Results 31 to 40 of about 22,649 (238)

Zoledronic acid in genitourinary cancer

Clinical and Translational Oncology, 2013
Bone metastases are a common complication of advanced prostate cancer and while they are less common in non-prostate genitourinary (GU) malignances, they have been reported in up to 35 % of patients with advanced renal cell carcinoma and bladder cancer.
Urbano Anido, M.J. Méndez-Vidal, Miguel Angel Climent, Javier Puente   +3 more
openaire   +5 more sources

Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay

BMC Cancer, 2009
Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients.
Dexel Susanne, Reichelt Ralf, Fernando Augusta, Glaysher Sharon, Kurbacher Christian M, Knight Louise A, Reinhold Uwe, Cree Ian A   +7 more
doaj   +1 more source

Symmetry Scheme for Amino Acid Codons [PDF]

Phys.Rev.E65, 021912 (2002), 2003
Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv   +1 more source

Expert Perspective: How, When, and Why to Potentially Stop Antiresorptive Drugs in Osteoporosis

Arthritis &Rheumatology, EarlyView.
Osteoporosis is a chronic disease, and antiresorptive treatments are often continued for many years. Despite their established efficacy in reducing fracture risk, the most commonly used antiresorptive treatments, bisphosphonates and denosumab, have short‐ and long‐term risks that, coupled with their benefits and other unique characteristics, influence ...
Giovanni Adami, Kenneth G. Saag
wiley   +1 more source

Zoledronic acid in breast cancer: latest findings and interpretations

Therapeutic Advances in Medical Oncology, 2011
The intravenous nitrogen-containing bisphosphonate zoledronic acid has been shown to block multiple steps in tumor metastasis (e.g. angiogenesis, invasion, adhesion, proliferation) in preclinical and translational studies.
Michael Gnant
doaj   +1 more source

Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]

arXiv, 2023
Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv  

Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates

Drug Testing and Analysis, EarlyView.
The detection of bisphosphonates is important due to the potential integrity and welfare issues associated with use of these substances. Targeted detection of a nitrogenous and non‐nitrogenous bisphosphonate was detected for 8 h and 28 days post‐administration, respectively.
Kathy Tou, Adam Cawley, Glenys Noble, Jaymie Loy, David Bishop, John Keledjian, Kireesan Sornalingam, Stacey Richards, Shanlin Fu   +8 more
wiley   +1 more source

Seizures Associated with Zoledronic Acid for Osteoporosis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2011
Bisphosphonates represent potent antiresorptive drugs that are established for therapy of patients with benign and malignant bone diseases. Zoledronic acid is an iv aminobisphosphonate that is administered annually against osteoporosis. Because of its potency and the parenteral route of administration, zoledronic acid is an alternative to oral ...
Lorenz C. Hofbauer, Tilman D. Rachner, Matthias Gruber, Christine Hamann, Elena Tsourdi, Tjalf Ziemssen   +5 more
openaire   +3 more sources

A Case of Advanced Renal Cell Carcinoma With Concomitant Development of Multiple Endocrine Neoplasia Type 1 That Affected Treatment Progress With Immunotherapy

IJU Case Reports, EarlyView.
ABSTRACT Introduction Hypercalcemia is a poor prognostic factor in advanced cancer. Case Presentation A patient with advanced clear cell renal carcinoma with hypercalcemia was treated with nivolumab+ipilimumab combination therapy. Treatment was discontinued after 4 months due to renal dysfunction.
Masataka Abe, Yoshiyuki Miyaji, Seitetsu Sugiyama, Kiwami Tsurui, Hirofumi Morinaka, Mikako Kaifu, Hiroyuki Kadoya, Wataru Saito, Koji Yoshida, Kazumasa Komura   +9 more
wiley   +1 more source

Systematic in‐hospital screening and treatment for osteoporosis in a geriatric population with hip fractures

Journal of Hospital Medicine, EarlyView.
Abstract Background Low‐trauma fractures of the hip signify osteoporosis and increase the risk of a second fracture. However, screening for secondary osteoporosis and initiating osteoporosis treatment can be challenging in a geriatric population.
Jeppe B. Rosenbæk, Line B. Dalgaard, Anne Grauballe, Stella J. Wilfred, Mikkel W. Ibsen, Lene R. Madsen   +5 more
wiley   +1 more source