Denosumab versus zoledronic acid in elderly patients after hip fracture
Journal of Orthopaedic Surgery, 2022 Background Two injectable anti-osteoporosis medications, denosumab and zoledronic acid, have been widely used to treat patients with severe osteoporosis.
Seung-Ju Kim, Ji Woon Kim, Dong-Woo Lee
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Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Zoledronic acid, one of the most potent nitrogen-containing biphosphonates, has been demonstrated to have direct anti-tumor and anti-metastatic properties in breast cancer in vitro and in vivo.
Yu-Guang Ma +10 more
doaj +1 more source
Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells [PDF]
, 2017 Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice.
Abdullah, MI, Abed, MN, Richardson, A
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Journal of the American Medical Association (JAMA), 2020 Importance A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.
G. Cai +13 more
semanticscholar +1 more source
Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review
BMC Cancer, 2020 Zoledronic acid (ZA) is one of the most important and effective class of anti-resorptive drug available among bisphosphonate (BP), which could effectively reduce the risk of skeletal-related events, and lead to a treatment paradigm for patients with ...
Lianwei Wang +3 more
semanticscholar +1 more source
Does industry-sponsored education foster overdiagnosis and overtreatment of depression, osteoporosis and over-active bladder syndrome? An Australian cohort study [PDF]
, 2018 ObjectivesTo investigate patterns of industry-sponsored educational events that focus on specific health conditions for which there are concerns about overdiagnosis and overtreatment.Design and settingThis retrospective cohort study examines publicly ...
Bero, Lisa +5 more
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Science Advances, 2020 Combining BMP-2 and zoledronic acid is a recipe for creating “synthetic autologous bone” to treat large bone defects. Bone morphogenic proteins (BMPs) are the only true osteoinductive molecules.
D. Raina +7 more
semanticscholar +1 more source
Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort [PDF]
, 2018 Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications ...
Fox, Edward J. +5 more
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Dosing of zoledronic acid with its anti-tumor effects in breast cancer
Journal of Bone Oncology, 2015 Bisphosphonates have played an important role in the treatment of breast cancer, mainly in patients with bone metastasis, by reducing the risk of fracture, spinal cord compression, and hypercalcemia.
Xinmin Zhao, Xichun Hu
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A systematic review of the effectiveness of docetaxel and mitoxantrone for the treatment of metastatic hormone-refractory prostate cancer [PDF]
, 2006 A systematic review was performed to evaluate the clinical effectiveness of docetaxel in combination with prednisolone (docetaxel is licensed in the UK for use in combination with prednisone or prednisolone for the treatment of patients with metastatic ...
A Birtle +19 more
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