Results 71 to 80 of about 5,138,607 (284)

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

An in vivo assay for osteoclast activity using mouse calvaria

Animal Models and Experimental Medicine, EarlyView.
This study describes a novel method for measuring osteoclast‐mediated bone resorption in vivo using a mouse model. Localized injection of RANKL in a basement membrane matrix above the cranium induced osteoclast‐mediated bone resorption. Utilizing micro‐computed tomography and a semiautomated three‐dimensional analysis program, osteoclast resorption pit
Christopher Grieg, Maya Deza Culbertson, J. Patrick O'Connor   +2 more
wiley   +1 more source

Acute unilateral anterior uveitis following zoledronic acid infusion: A case report

SAGE Open Medical Case Reports, 2020
Bisphosphonates are widely used to treat several clinical conditions. Zoledronic acid is one of this class, commonly used for the treatment and prevention of osteoporosis, hypercalcemia of malignancy, Paget’s disease, and multiple myeloma.
Kiruththihan Anandasayanan, Muthusamy Malaravan, Navaneethakrishnan Suganthan   +2 more
doaj   +1 more source

Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy

Journal of Bone and Mineral Research, 2020
Carboplatin is a chemotherapy drug used to treat solid tumors but also causes bone loss and muscle atrophy and weakness. Bone loss contributes to muscle weakness through bone‐muscle crosstalk, which is prevented with the bisphosphonate zoledronic acid ...
Brian A. Hain, B. Jude, Haifang Xu, Dallas Smuin, Edward J. Fox, J. Elfar, David L. Waning   +6 more
semanticscholar   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Lessons learned from long-term side effects after zoledronic acid infusion following denosumab treatment: a case report and review of the literature

Journal of Medical Case Reports, 2022
Background Zoledronic acid is an intravenous, highly potent aminobisphosphonate for use in patients with primary or secondary osteoporosis. Zoledronic acid-induced prolonged side-effects are well known and quite common.
Ilona Nurmi-Lüthje, Peter Lüthje
doaj   +1 more source

The dental management of patients at risk of medication-related osteonecrosis of the jaw: New paradigm of primary prevention [PDF]

, 2018
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is a potentially painful and debilitating condition that can considerably affect the quality of life of patients ...
Bedogni, Alberto, Campisi, Giuseppina, Di Fede, Olga, Fusco, Vittorio, Lo Muzio, Lorenzo, Mauceri, Rodolfo, Panzarella, Vera, Sipmo Onj Board, Null   +7 more
core   +2 more sources

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements [PDF]

, 2015
INTRODUCTION: Our objective was to determine effects of zoledronic acid (ZA) on atrial electrophysiological parameters and electrocardiographic measurements.
Allen, Matthew R., Jaynes, Heather A., Kovacs, Richard J., Overholser, Brian R., Tisdale, James E.   +4 more
core   +1 more source

Reduction effect of oral pravastatin on the acute phase response to intravenous zoledronic acid: protocol for a real-world prospective, placebo-controlled trial [PDF]

, 2022
Qi Liu, Gengyu Han, Runting Li, Dongwei Fan, Guohong Du, Min Zhang, Liyuan Tao, Haiyan Li, Dongyang Liu, Chunli Song   +9 more
openalex   +1 more source