Results 81 to 90 of about 5,138,607 (284)

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Comprehensive evaluation of compound Kushen injection combined with zoledronic acid in treating bone metastasis cancer pain based on meta-analysis and decision tree model

Frontiers in Pain Research
ObjectiveTo evaluate the safety, efficacy, and cost-effectiveness of combining Compound Kushen Injection (CKI) with zoledronic acid in the treatment of bone metastasis-induced cancer pain in malignant tumors.MethodsA comprehensive search of Chinese and ...
Xi Zhao, Tianwei Meng, Kaiqiang Wang, Xi Yan, Yuqiang Liu, Xinghua Li   +5 more
doaj   +1 more source

RTOG 0518: Randomized Phase III Trial to Evaluate Zoledronic Acid for Prevention of Osteoporosis and Associated Fractures in Prostate Cancer Patients [PDF]

, 2014
Background: RTOG 0518 evaluated the potential benefit of zoledronic acid therapy in preventing bone fractures for patients with high grade and/or locally advanced, non-metastatic prostate adenocarcinoma receiving luteinizing hormone-releasing hormone ...
Gore, Elizabeth, Kachnic, Lisa A., Kim, Harold E., Lawton, Colleen AF, Martin, Andre-Guy, Nabid, Abdenour, Pugh, Stephanie L, Shah, Amit B., Smith, Matthew, Tai, Patricia   +9 more
core   +1 more source

NIR‐Responsive Nano‐Integrated Magnesium Phosphate Cement Promotes Bone Regeneration via Osteoblast‐Exosome‐Osteoclast Crosstalk

Rare Metals, EarlyView.
ABSTRACT The limited osteogenic capacity of magnesium phosphate cement (MPC) has constrained its biomedical applications, underscoring the necessity to develop MPC with enhanced physical properties and bone‐forming capabilities. In this study, a multifunctional MPC system was developed by incorporating zoledronic acid‐loaded near‐infrared (NIR ...
Bin Wang, Shun‐Jie Wu, Xin‐Lin Lu, Yong Ge, Yue Zhang, Zhi‐Xiang Ma, Bin Xu, Paul‐K. Chu, Yan‐Bin Zhao   +8 more
wiley   +1 more source

Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model

Journal of Orthopaedic Translation, 2021
Background: Osteonecrosis of the femoral head (ONFH) is a refractory disease due to its unclear pathomechanism. Neither conservative treatment nor surgical treatment during the early stage of ONFH achieves satisfactory results. Therefore, this study aims
Jun Zhao, Tian Yue, Shibi Lu, Haoye Meng, Qiuxia Lin, Haiyang Ma, Guangbo Liu, Huo Li, Qiang Lu, Aiyuan Wang, Wenjing Xu, Jing Feng, Yiqun Wan, Sida Liao, Xuefeng Zhou, Jiang Peng   +15 more
doaj   +1 more source

Antitumor Effects of Clinical Dosing Regimens of Bisphosphonates in Experimental Breast Cancer Bone Metastasis [PDF]

, 2017
Background Bisphosphonates exhibit direct antitumor activity in animal models, but only at high doses that are incompatible with the clinical dosing regimens approved for the treatment of cancer patients with skeletal metastases.
Clézardin, Philippe, Daubiné, Florence, Gasser, Juerg, Green, Jonathan, Le Gall, Céline   +4 more
core  

Anti-tumour activity of bisphosphonates in preclinical models of breast cancer [PDF]

, 2010
There is increasing evidence of anti-tumour effects of bisphosphonates from pre-clinical studies, supporting a role for these drugs beyond their traditional use in treatment of cancer-induced bone disease.
A Sasaki, A Sasaki, AC Hirbe, AJ Roelofs, C Melani, C Walter, D Santini, D Santini, DW Dempster, ER van Beek, EY Lin, F Daubiné, G Facchini, G Morgan, G Rennert, G van der Pluijm, GR Mundy, GR Mundy, H Eidtmann, H Mönkkönen, H Neville-Webbe, HK Brown, HL Benford, HM Weiss, Ingunn Holen, J Dai, J Soltau, J Wood, J Yamada, JH Lin, JM Tuomela, K Thompson, M Coscia, M Gnant, M Michailidou, M Neudert, MC Winter, MJ Simon, P Clézardin, PA Newcomb, PD Ottewell, PD Ottewell, PD Ottewell, PD Ottewell, PD Ottewell, PI Croucher, PP Provenzano, R Aft, RD Leek, RE Coleman, Robert E Coleman, S Meraviglia, SB Coffelt, SP Luckman, T Bäuerle, T Chen, T Hiraga, T Hiraga, T Hiraga, T Powles, T Ziebart, TL Aghaloo, V Kunzmann, WC Duivenvoorden, X Tang   +64 more
core   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Supplementary Figure 1 from Zoledronic Acid Has Differential Antitumor Activity in the Pre- and Postmenopausal Bone Microenvironment <i>In Vivo</i> [PDF]

, 2023
Penelope D. Ottewell, Ning Wang, Hannah K. Brown, Kimberly J. Reeves, C. Anne Fowles, Peter I. Croucher, Colby L. Eaton, Ingunn Holen   +7 more
openalex   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source