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Current Treatment Options in Gastroenterology, 2003
Zollinger-Ellison syndrome (ZES) is caused by a gastrin-producing tumor called a gastrinoma, which results in gastric acid hypersecretion. Gastrin stimulates the parietal cell to secrete acid directly and indirectly by releasing histamine from enterochromaffin-like (ECL) cells, and induces hyperplasia of parietal and ECL cells.
Patrick D., Hung +2 more
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Zollinger-Ellison syndrome (ZES) is caused by a gastrin-producing tumor called a gastrinoma, which results in gastric acid hypersecretion. Gastrin stimulates the parietal cell to secrete acid directly and indirectly by releasing histamine from enterochromaffin-like (ECL) cells, and induces hyperplasia of parietal and ECL cells.
Patrick D., Hung +2 more
openaire +2 more sources
The Lancet, 1964
Few clinical states have aroused more interest and curiosity among physicians than has the Zollinger-Ellison syndrome. In the eight years since its description in 1955, pathologists, physiologists, and clinicians have become very much aware of the intriguing relationship between endocrinopathy and peptic ulceration despite the fact that the syndrome is
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Few clinical states have aroused more interest and curiosity among physicians than has the Zollinger-Ellison syndrome. In the eight years since its description in 1955, pathologists, physiologists, and clinicians have become very much aware of the intriguing relationship between endocrinopathy and peptic ulceration despite the fact that the syndrome is
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Contributions of the Zollinger-Ellison syndrome
The American Journal of Surgery, 1991The salient contributions of the Zollinger-Ellison syndrome have made it unique. No pancreatic endocrine tumor described before (insulinoma) or subsequently (glucagonoma, somatostatinoma, vipoma, pancreatic-polypeptidoma) has been the topic of such a variety of studies, or has been such an inspiration and rich source of new ideas for investigation and ...
E, Passaro, B E, Stabile, T J, Howard
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Postgraduate Medicine, 1980
The Zollinger-Ellison syndrome (ZES) is characterized by gastrin-producing tumors, gastric acid hypersecretion, peptic ulcers, and diarrhea. ZES may be associated with nonpancreatic endocrine tumors as part of the multiple endocrine adenomatosis-type 1 syndrome.
J B, Marshall, R H, Settles
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The Zollinger-Ellison syndrome (ZES) is characterized by gastrin-producing tumors, gastric acid hypersecretion, peptic ulcers, and diarrhea. ZES may be associated with nonpancreatic endocrine tumors as part of the multiple endocrine adenomatosis-type 1 syndrome.
J B, Marshall, R H, Settles
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Nesidioblastosis and the Zollinger-Ellison syndrome
The American Journal of Digestive Diseases, 1968The most common cause of the Zollinger-Ellison syndrome is the over-production of a gastrin-like hormone by a non-beta islet cell neoplasm of the pancreas. Hyperplasia and neoformation of islets alone and in combination with neoplasia have been reported in association with the syndrome, but there has been little effort to implicate these findings in ...
R E, Brown, W J, Still
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Zollinger-Ellison syndrome with pneumopericardium
Digestive Diseases and Sciences, 1979A 55-year-old white male was found to have the Zollinger-Ellison syndrome in 1971. Supposed total gastrectomy was performed at that time. When an esophageal ulcer was found, six years later, esophagoscopic biopsy revealed residual gastric mucosa. The patient was given cimetidine 300 mg qid because it was felt he could not tolerate further surgery ...
J D, Green +3 more
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Metiamide in the Zollinger-Ellison syndrome
The American Journal of Digestive Diseases, 1975The histamine H2-receptor antagonist metiamide is an inhibitor of endogenous and stimulated gastric-acid secretion. It appears to have therapeutic possibilities in duodenal-ulcer disease. Three patients exhibiting the Zollinger-Ellison syndrome have been treated with this drug for six months or more. Rapid symptomatic improvement occurred in each case,
E L, Blair +6 more
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Hypergastrinemia and the Zollinger-Ellison Syndrome
Archives of Surgery, 1972To the Editor. —Because of the wellrecognized pitfalls inherent in overdependence upon various demonstrations of gastric hypersecretion, adaptation of radioimmunoassay techniques to the quantization of serum gastrin levels has been readily accepted as another means of diagnostic screening in patients with historical features and secretory studies ...
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Diagnosis of the Zollinger–Ellison Syndrome
Clinical Gastroenterology and Hepatology, 2012Clinical Scenario A man is referred to you for evaluation of possible Zollinger–Ellison syndrome (ZES).1 He gives an 8-year history of heartburn, for which he has been receiving increasing doses of proton pump inhibitor (PPI) therapy. Over the past few months he has noted worsening symptoms of heartburn and regurgitation, especially at night or after ...
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