Results 221 to 230 of about 62,762 (291)

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Intraoperative quantitative angiography predicts midterm left subclavian artery patency after thoracic endovascular aortic repair. [PDF]

Quant Imaging Med Surg
Zhao J, Fang K, Luo M, Liu J, Chen D, Shu C.   +5 more
europepmc   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

Master Splinter and the challenge of personalization in education

Frontiers in Psychology
Stefano Triberti, Raffaele Di Fuccio
doaj   +1 more source

Branched Endovascular Aneurysm Repair (BEVAR) to Rescue Failed Complex EVAR (C-EVAR): Technical Challenges and Outcomes in a 12-Case Series. [PDF]

J Clin Med
Usai MV, Expósito-Camacho B, Franke P, Ritonga ITP, Balaguer-Germán J, Austermann MJ.   +5 more
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Do Early Aortic Remodelling Patterns at 6 Months Predict Mid-Term Outcomes After Frozen Elephant Trunk for Chronic Aortic Dissection? [PDF]

Interdiscip Cardiovasc Thorac Surg
Akita S, Tokuda Y, Tamenishi A, Matsumura Y, Hayakawa A, Mutsuga M.   +5 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis. [PDF]

Nat Commun
Suhardi VJ, Oktarina A, Niu Y, Thomson AL, Alphonsus J, Suhardi N, McCormick J, Ayturk U, Greenblatt MB, Ivashkiv LB, Bostrom MPG, Yang X.   +11 more
europepmc   +1 more source

Mechanobiological evaluation of solid and multiple porous humeral stem architectures in reverse shoulder arthroplasty based on design and materials: a finite element study. [PDF]

Front Bioeng Biotechnol
John PB, Nageswaran S.
europepmc   +1 more source