Results 41 to 50 of about 161,238 (304)
MRI Compatible Planar Material Acoustic Lenses
Applied Sciences, 2018 Zone plate lenses are used in many areas of physics where planar geometry is advantageous in comparison with conventional curved lenses. There are several types of zone plate lenses, such as the well-known Fresnel zone plates (FZPs) or the more recent ...
Daniel Tarrazó-Serrano +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Rotational Sweep Rotating Zone Plate Sequence
Tongxin xuebao, 1995 This paper presents the principle and method of setting up a mathematical model of rotational sweep rotating zone plate in polar coordinate system. The new zone plate developed contains all spatial fraquencies,and can truly rotate at different speeds ...
李桂苓, 周志河
doaj +2 more sources
Growth plate closure and therapeutic interventions [PDF]
Clinical and Experimental PediatricsHeight gains result from longitudinal bone growth, which is largely dependent on chondrocyte differentiation and proliferation within the growth plates of long bones. The growth plate, that is, the epiphyseal plate, is divided into resting, proliferative,
Ja Hyang Cho +2 more
doaj +1 more source
Geochemistry, Geophysics, Geosystems, 2023 To better understand the structure and process of the Cocos plate subduction, we obtained the first Pn velocity and anisotropy model of the uppermost mantle in southern Mexico using the Pn tomography method and new ISC‐EHB data.
Yan Lü +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
Simple and Efficient Realization of Transverse Linear Dark Beams by Azimuthal Phase-Shifted Square Zone Plate [PDF]
, 2021 Shahrbanoo Asghari, Arash Sabatyan
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source