Results 61 to 70 of about 479,302 (269)

Spatial Patterns of Structural Complexity in Differently Managed and Unmanaged Beech-Dominated Forests in Central Europe

open access: yesRemote Sensing, 2020
One of the main goals of modern silviculture is to emulate the structural complexity of old-growth forests. In this context, it is of advantage to identify a target state of structural complexity at the stand level and to analyze the spatial ...
Katharina Willim   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Study of blades inclination influence of gate impeller with a non-Newtonian fluid of Bingham

open access: yesEPJ Web of Conferences, 2016
A large number of chemical operations, biochemical or petrochemical industry is very depending on the rheological fluids nature. In this work, we study the case of highly viscous of viscoplastic fluids in a classical system of agitation: a cylindrical ...
Rahmani Lakhdar   +3 more
doaj   +1 more source

Zones of biosynthesis [PDF]

open access: yesNature Reviews Cancer, 2020
Morral, Stanisavljevic et al. show that colorectal cancer (CRC) cell hierarchy is based on the capacity to perform biosynthesis. Undifferentiated CRC cells that have high capacity for protein synthesis were found immediately adjacent to the stroma, and this capacity was lost upon differentiation.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Looser’s Zone

open access: yesOman Medical Journal, 2010
Osteomalacia is usually neglected when compared with other metabolic bone diseases and may present with a variety of clinical and radiographic manifestations mimicking other musculoskeletal disorders. It is a known cause of persistent, nonspecific musculoskeletal pain.
Fayaz Sofi   +3 more
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Qualité de la viande de dromadaire dans les abattoirs de Ouargla en Algérie. II. Contamination bactérienne superficielle des carcasses

open access: yesRevue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015
Dans le but d’apprécier la qualité microbiologique de la viande de dromadaire produite à l’abattoir de la wilaya de Ouargla en Algérie, la contamination superficielle d’origine bactérienne de 60 carcasses camelines a été évaluée.
A. Benaissa   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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