Results 11 to 20 of about 28,285 (214)

Effect of Glucagon-like Peptide 2 on Tight Junction in Jejunal Epithelium of Weaned Pigs though MAPK Signaling Pathway [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
The glucagon-like peptide 2 (GLP-2) that is expressed in intestine epithelial cells of mammals, is important for intestinal barrier function and regulation of tight junction (TJ) proteins. However, there is little known about the intracellular mechanisms
Changsong Yu, Gang Jia, Yi Jiang, Qiuhong Deng, Zhengli Chen, Zhiwen Xu, Xiaolin Chen, Kangning Wang   +7 more
doaj   +1 more source

Astragalus polysaccharides and astragaloside IV ameliorates cyclophosphamide-induced mouse model of overactive bladder

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: Previous studies have shown that Astragalus polysaccharides (APS) and Astragaloside IV (AS-IV) protect against inflammation-related cell damage and exhibit immune enhancement.
Yung-Hsiang Chen, Wen-Chi Chen, Po-Len Liu, Huey-Yi Chen   +3 more
doaj   +1 more source

Supplementation of postbiotic RI11 improves antioxidant enzyme activity, upregulated gut barrier genes, and reduced cytokine, acute phase protein, and heat shock protein 70 gene expression levels in heat-stressed broilers

Poultry Science, 2021
The aim of this work was to evaluate the impacts of feeding different levels of postbiotic RI11 on antioxidant enzyme activity, physiological stress indicators, and cytokine and gut barrier gene expression in broilers under heat stress.
Ali Merzza Humam, Teck Chwen Loh, Hooi Ling Foo, Wan Ibrahim Izuddin, Idrus Zulkifli, Anjas Asmara Samsudin, Noordin Mohamed Mustapha   +6 more
doaj   +1 more source

Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]

, 2015
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola, Caparrotta, Laura, Carrara, Maria, Castagliuolo, Ignazio, Catanzaro, Daniela, Dall'Acqua, Stefano, Giron, Maria Cecilia, Montopoli, Monica, Orso, Genny, Ragazzi, Eugenio, Serena, Rancan   +10 more
core   +5 more sources

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds.
Jingbo Jiang, Daniel Hoagland, Joseph A. Palatinus, Huamei He, Jegan Iyyathurai, L. Jane Jourdan, Geert Bultynck, Zhen Wang, Zhiwei Zhang, Kevin Schey, Steven Poelzing, Francis X. McGowan, Robert G. Gourdie   +12 more
doaj   +1 more source

Loss and reappearance of gap junctions in regenerating liver [PDF]

, 1978
Changes in intercellular junctional morphology associated with rat liver regeneration were examined in a freeze-fracture study. After a two-thirds partial hepatectomy, both gap junctions and zonulae occludentes were drastically altered.
Revel, J.-P., Yee, A. G.
core   +2 more sources

Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
Silencing Zonula occludens 2 (ZO-2), a tight junctions (TJ) scaffold protein, in epithelial cells (MDCK ZO-2 KD) triggers: 1) Decreased cell to substratum attachment, accompanied by reduced expression of claudin-7 and integrin β1, and increased vinculin recruitment to focal adhesions and stress fibers formation; 2) Lowered cell-cell aggregation and ...
Raya-Sandino, A., Castillo-Kauil, A., Domínguez-Calderón, A., Alarcón, L., Flores-Benitez, D., Cuellar-Perez, F., López-Bayghen, B., Chávez-Munguía, B., Vázquez-Prado, J., González-Mariscal, L.   +9 more
openaire   +3 more sources

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis

Gastroenterology Research and Practice, 2021
Curcumin is a natural polyphenol and is supposed to possess antioxidant, anti-inflammatory, anticancer, and antiapoptotic properties. Although some studies have reported the therapeutic effects of curcumin on ulcerative colitis (UC), the specific ...
Xinxin Zhou, Mengting Ren, Jinpu Yang, Hanghai Pan, Mosang Yu, Feng Ji   +5 more
doaj   +1 more source

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption [PDF]

, 2020
The epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. Campylobacter concisus is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Genger, Claudia, Heimesaat, Markus M., Kløve, Sigri, Lee, In-Fah Maria, Lobo de Sá, Fábia Daniela, Mousavi, Soraya, Nagel, Oliver, Nattramilarasu, Praveen Kumar, Nielsen, Hans Linde, Schulzke, Jörg-Dieter, Schweiger, Michal R., Troeger, Hanno   +15 more
core   +2 more sources