Results 31 to 40 of about 57,655 (294)
Tropical Medicine and Infectious Disease, 2023 Tuberculosis (TB), a zoonosis characterized by chronic respiratory infections, is mainly caused by Mycobacterium tuberculosis and is associated with one of the heaviest disease burdens in the world.
Chuang Meng +8 more
doaj +1 more source
TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway
Brain Sciences, 2021 Background: TREM2 expressed on microglia plays an important role in modulating inflammation in neurodegenerative diseases. It remains unknown whether TREM2 modulates hyperglycemia-induced microglial inflammation.
Yuan Li +6 more
doaj +1 more source
Advanced Science, EarlyView.Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou +11 more
wiley +1 more source
Virology Journal, 2019 Background Rabies virus (RABV), a member of Lyssavirus of Rhabdoviridae family, is a kind of negative-strand RNA virus. The zoonosis caused by RABV leads to high mortality in animals and humans.
Jie Gao +7 more
doaj +1 more source
Effect of Circular RNA hsa_circ_004389 on Replication of Influenza A Virus
Guangdong nongye kexue, 2022 【Objective】Based on the preliminary transcriptome profiles of A549 cells responding to influenza A virus (IAV) infection, one of the most significantly up-regulated host circular RNA(circRNA), hsa_circ_004389, was selected to further validate its ...
Shu ZHANG +5 more
doaj +1 more source
Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
Advanced Science, EarlyView.MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang +7 more
wiley +1 more source
Medwave, 2003 Ecological, climatic and sociocultural changes, have enhanced the number of known zoonoses being over 200 at the present. Transmission of infectious agents from animals to man occurs by direct contact with the animal, o by ingestion, inhalation or inoculation of infectious agent. In the Región Metropolitana 71 percent of houses with children have pets,
openaire +2 more sources
Molecular determinants of cellular attachment-mediated zoonosis of emerging paramyxo- and arenaviruses. [PDF]
, 2019 The spillover of viral pathogens from wild animal reservoirs into human populations is the predominant cause of emerging disease events worldwide and represents an acute and persistent threat to global health, economy, and biodefence.
Pryce, Rhys
core +1 more source
Advanced Science, EarlyView.A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan +7 more
wiley +1 more source