Results 51 to 60 of about 51,382 (301)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Criptosporidiosis: una zoonosis emergente Cryptosporidiosis: an emerging zoonosis

Revista Argentina de Microbiología, 2009
El género Cryptosporidium, responsable de la criptosporidiosis, abarca diversas especies. El ganado vacuno y el hombre constituyen las principales fuentes de infección.
V. F. Del Coco, M. A. Córdoba, J. A. Basualdo   +2 more
doaj  

Investigation of the piroplasm diversity circulating in wildlife and cattle of the greater Kafue ecosystem, Zambia

Parasites & Vectors, 2020
Background Piroplasms are vector-borne intracellular hemoprotozoan parasites that infect wildlife and livestock. Wildlife species are reservoir hosts to a diversity of piroplasms and play an important role in the circulation, maintenance and evolution of
David Squarre, Yukiko Nakamura, Kyoko Hayashida, Naoko Kawai, Herman Chambaro, Boniface Namangala, Chihiro Sugimoto, Junya Yamagishi   +7 more
doaj   +1 more source

Development of Woolly Hair and Hairlessness in a CRISPR−Engineered Mutant Mouse Model with KRT71 Mutations

Cells, 2023
Hypotrichosis simplex (HS) and woolly hair (WH) are rare and monogenic disorders of hair loss. HS, characterized by a diffuse loss of hair, usually begins in early childhood and progresses into adulthood.
Tao Zhang, Hongwu Yao, Hejun Wang, Tingting Sui   +3 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

The inactivated and ISA 61 VG adjuvanted vaccine enhances protection against cross-serotype Listeria monocytogenes

Veterinary Research
Listeriosis is a zoonotic disease caused by Listeria monocytogenes (Lm), posing a significant threat to the breeding industry and public health. Ruminant livestock are particularly susceptible to Lm,  thus effective strategies are needed for controlling ...
Fanzeng Meng, Ye Wang, Chao Chen, Tianxiang Pan, Jing Li, Yao Xu, Zegang Wang, Hao Yao, Xin’an Jiao, Yuelan Yin   +9 more
doaj   +1 more source

The mucin-like, secretory type-I transmembrane glycoprotein GP900 in the apicomplexan Cryptosporidium parvum is cleaved in the secretory pathway and likely plays a lubrication role

Parasites & Vectors, 2022
Background Cryptosporidium parvum is a zoonotic parasite and member of the phylum Apicomplexa with unique secretory organelles, including a rhoptry, micronemes and dense granules that discharge their contents during parasite invasion.
Xiaohui Li, Jigang Yin, Dongqiang Wang, Xin Gao, Ying Zhang, Mingbo Wu, Guan Zhu   +6 more
doaj   +1 more source

Causal analysis of trade loss from pathogens: A global study of foot and mouth disease impacts on meat exports

American Journal of Agricultural Economics, EarlyView.
Abstract Our general interest is in global trade loss from livestock pathogens, specifically exports. We adopt a causal inference approach that considers animal disease outbreaks over time as non‐staggered binary treatments with the potential for switching in (infection) and out of treatment (recovery) within the sample period. The outcome evolution of
Mohammad Maksudur Rahman, Thomas L. Marsh   +1 more
wiley   +1 more source

Acute shock caused by Clonorchis sinensis infection: a case report

BMC Infectious Diseases, 2019
Background Clonorchiasis, caused by Clonorchis sinensis (C. sinensis) infection, is a serious food-borne zoonotic disease that is often asymptomatic or shows only mild symptoms, which leads to delayed treatment and chronic clonorchiasis and results in ...
Nan Wang, Bin Tang, Yuhua Hao, Xue Bai, Xuelin Wang, Yuxiang Li, Yong Yang, Shicun Li, Shuo Hao, Xinyu Wang, Mingyuan Liu, Xiaolei Liu   +11 more
doaj   +1 more source

Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats

Lipids in Health and Disease, 2018
Background An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the ...
Yanan An, Yan Li, Xueyan Wang, Zhaobin Chen, Hongyue Xu, Lingyu Wu, Shulin Li, Chao Wang, Wenjing Luan, Xuefei Wang, Mingyuan Liu, Xudong Tang, Lu Yu   +12 more
doaj   +1 more source