Results 11 to 20 of about 394,438 (273)
Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
OncoImmunology, 2020 Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially ...
Zoila A. Lopez-Bujanda +5 more
doaj +1 more source
Algorithmic asymptotic analysis: extending the arsenal of cancer immunology modeling [PDF]
Journal of Theoretical Biology Volume 534, 7 February 2022, 110975, 2021 The recent advances in cancer immunotherapy boosted the development of tumor-immune system models aiming to provide mechanistic understanding and indicate more efficient treatment regimes. However, the complexity of such models, their multi-scale dynamics and their overparameterized character renders them inaccessible for wide utilization. In this work,
arxiv +1 more source
Epithelial-to-mesenchymal transition and its association with PD-L1 and CD8 in thyroid cancer
Endocrine Connections, 2020 Programmed cell death-ligand 1 (PD-L1) has recently been shown to play a role in the regulation of epithelial-to-mesenchymal transition (EMT); however, the relationship between PD-L1 expression, EMT and the inflammatory tumour microenvironment has yet to
Marra Jai Aghajani +7 more
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Mathematical modeling of tumor-immune system interactions: the effect of rituximab on breast cancer immune response [PDF]
, 2021 tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as well as CD8$^+$ T cells, CD4$^+$ T ...
arxiv +1 more source
Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]
npj Systems Biology and Applications, 10(1), 105 (2024), 2023 As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv +1 more source
OncoImmunology, 2017 The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS).
Anne Gomez-Brouchet +19 more
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Инфекция и иммунитет, 2017 Infectious mononucleosis is a widespread disease caused by certain members of Herpesviridae family. Acute infectious mononucleosis develops predominantly in children and is accompanied by an increase of the number of circulating naive CD4+ and naive CD8+
E. N. Filatova +4 more
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A statistical analysis of memory CD8 T cell differentiation: An application of a hierarchical state space model to a short time course microarray experiment [PDF]
Annals of Applied Statistics 2007, Vol. 1, No. 2, 442-458, 2007 CD8 T cells are specialized immune cells that play an important role in the regulation of antiviral immune response and the generation of protective immunity. In this paper we investigate the differentiation of memory CD8 T cells in the immune response using a short time course microarray experiment.
arxiv +1 more source
Schopenhauer and I. Kant in A. A. Fet’s philosophical and political worldview (conclusion) [PDF]
Кантовский сборник, 2013 The concluding part of the work focuses on the independence of A. A. Fet’s philosophical worldview strongly emphasised by the poet himself and his close friends. Although he quotes Schopenhauer and Kant, he criticised them and demonstrates an independent
Kalinnikov L.
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Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022 Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han +5 more
wiley +1 more source