Immunoglobulin heavy chains in medaka (
BMC Evolutionary Biology, 2011 Background Bony fish present an immunological system, which evolved independently from those of animals that migrated to land 400 million years ago.
Gambón-Deza Francisco +2 more
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Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies. [PDF]
PLoS Computational Biology, 2022 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo +3 more
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Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1975 Cells of the MPC-11 mouse myeloma cell line, which produces an IgG2b immunoglobulin, were subjected to mutagenesis with Melphalan or with ICR-191, after which they were cloned in soft agar.
Jean‐Louis Preud'homme +2 more
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SUBGROUPS OF AMINO ACID SEQUENCES IN THE VARIABLE REGIONS OF IMMUNOGLOBULIN HEAVY CHAINS
Proceedings of the National Academy of Sciences of the United States of America, 1969 The amino acid sequence of the first 133 residues of the heavy (gamma) chain from a human gammaG immunoglobulin (He) has been determined. This gamma-chain is identical in Gm type to that of protein Eu, the complete sequence of which has been reported ...
Bruce A. Cunningham +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 1974 The variable regions of five human immunoglobulin heavy chains of the V(H)III subgroup have been totally sequenced. Three of the heavy chains belonged to the IgG class and two to the IgA class.
J. Donald Capra, J. Michael Kehoe
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Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1979 To investigate the organization of immunoglobulin genes, we have constructed a clone library containing 10(6) randomly generated fragments of mouse embryo DNA, corresponding to eight equivalents of the genome.
Darrell J. Kemp +2 more
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The Translation in vitro of mRNA for Immunoglobulin Heavy Chains [PDF]
European Journal of Biochemistry, 1973 The addition of mRNA preparations to a number of heterologous cell‐free systems has been shown to result in the synthesis of immunoglobulin light chains. This paper reports the results of experiments in which an mRNA fraction prepared from MOPC 21 mouse myeloma cells has been used to stimulate the synthesis of immunoglobulin heavy chains in rabbit ...
N.J. Cowan, Cesar Milstein
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Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein. [PDF]
Journal of Cell Biology, 1987 Heavy chain-binding protein (BiP) associates posttranslationally with nascent Ig heavy chains in the endoplasmic reticulum (ER) and remains associated with these heavy chains until they assemble with light chains.
Linda M. Hendershot +3 more
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Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America, 1976 The entire sequences of the heavy chain variable regions of M167 and TEPC 15 (phosphorylcholine-binding myeloma proteins of BALB/c origin) have been determined. These sequences are compared with the phosphorylcholine-binding protein M603.
Stuart Rudikoff, Michael Potter
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Polymorphism in immunoglobulin heavy chains suggesting gene conversion. [PDF]
Proceedings of the National Academy of Sciences, 1982 Complete heavy (H) chain variable region (V region; amino acids 1-118) sequences have been determined for three phosphocholine (PCho)-binding monoclonal antibodies of CBA mouse strain origin. Two of these were found to differ from the sequence of the BALB/c T15 germline VH segment (segment of the V region that includes amino acids 1-95) at four ...
Clarke, S H, Claflin, J L, Rudikoff, S
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