Results 11 to 20 of about 22,523 (167)

Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury. [PDF]

Basic Res Cardiol
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolism by inhibiting succinate dehydrogenase (SDH) upon reperfusion using malonate is an effective therapeutic strategy to achieve ...
Abe J, Vujic A, Prag HA, Murphy MP, Krieg T.   +4 more
europepmc   +2 more sources

Genomic characterization of malonate positive Cronobacter sakazakii serotype O:2, sequence type 64 strains, isolated from clinical, food, and environment samples

Gut Pathogens, 2018
Background Malonate utilization, an important differential trait, well recognized as being possessed by six of the seven Cronobacter species is thought to be largely absent in Cronobacter sakazakii (Csak). The current study provides experimental evidence
Gopal R. Gopinath, Hannah R. Chase, Jayanthi Gangiredla, Athmanya Eshwar, Hyein Jang, Isha Patel, Flavia Negrete, Samantha Finkelstein, Eunbi Park, TaeJung Chung, YeonJoo Yoo, JungHa Woo, YouYoung Lee, Jihyeon Park, Hyerim Choi, Seungeun Jeong, Soyoung Jun, Mijeong Kim, Chaeyoon Lee, HyeJin Jeong, Séamus Fanning, Roger Stephan, Carol Iversen, Felix Reich, Günter Klein, Angelika Lehner, Ben D. Tall   +26 more
doaj   +2 more sources

Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/-galactosamine-induced acute hepatic damage in mice

Innate Immunity, 2019
In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation.
Yongqiang Yang, Ruyue Shao, Li Tang, Longjiang Li, Min Zhu, Jiayi Huang, Yi Shen, Li Zhang   +7 more
doaj   +2 more sources

Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer

Nature Communications, 2017
Some aerobic bacteria contain a biotin-independent malonate decarboxylase (MDC), which allows them to use malonate as the sole carbon source. Here, the authors present the crystal structure of a Pseudomonas MDC and give insights into its catalytic ...
Riyaz Maderbocus, Blanche L. Fields, Keith Hamilton, Shukun Luo, Timothy H. Tran, Lars E. P. Dietrich, Liang Tong   +6 more
doaj   +2 more sources

Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury

Circulation Research, 2022
Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for translation to the clinic is understanding the mechanism of malonate entry into
H. Prag, D. Aksentijević, Andreas Dannhorn, Abigail V Giles, J. Mulvey, Olga Sauchanka, Luping Du, Georgina R Bates, J. Reinhold, Duvaraka Kula-Alwar, Zhelong Xu, L. Pellerin, R. Goodwin, M. Murphy, T. Krieg   +14 more
semanticscholar   +1 more source

Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Neonatal mouse cardiomyocytes undergo a metabolic switch from glycolysis to oxidative phosphorylation, which results in a significant increase in reactive oxygen species production that ...
Jiyoung Bae, Rebecca J Salamon, Emma B. Brandt, Wyatt G. Paltzer, Ziheng Zhang, Emily C. Britt, T. Hacker, Jing Fan, A. Mahmoud   +8 more
semanticscholar   +1 more source

Asymmetric Hydrogenation of β-Aryl Alkylidene Malonate Esters: Installing an Ester Group Significantly Increases the Efficiency.

Organic Letters, 2021
Herein, we report a practical method for efficient asymmetric hydrogenation of β-aryl alkylidene malonates. With a site-specifically tailored chiral spiro iridium catalyst, a series of β-aryl alkylidene malonate esters were hydrogenated to afford chiral ...
Qiankun Zhao, Xiong Wu, Lin-Ping Li, Fan Yang, Jian-Hua Xie, Qi‐Lin Zhou   +5 more
semanticscholar   +1 more source

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo

Cardiovascular Drugs and Therapy, 2020
Purpose Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack.
H. Prag, L. Pala, Duvaraka Kula-Alwar, J. Mulvey, Luping Du, T. Beach, Lee M. Booty, A. Hall, A. Logan, Volha Sauchanka, S. Caldwell, Ellen L. Robb, A. James, Zhelong Xu, K. Saeb‐Parsy, R. Hartley, M. Murphy, T. Krieg   +17 more
semanticscholar   +1 more source

A Disjointed Pathway for Malonate Degradation by Rhodopseudomonas palustris

Applied and Environmental Microbiology, 2020
There is interest in understanding how bacteria metabolize malonate because this three-carbon dicarboxylic acid can serve as a building block in bioengineering applications to generate useful compounds that have an odd number of carbons.
Zhaobao Wang, Q. Wen, C. Harwood, Bo Liang, Jianming Yang   +4 more
semanticscholar   +1 more source

Neutron-neutron quasifree scattering in neutron-deuteron breakup at 10 MeV [PDF]

Phys. Rev. C 101 (2020) 034002, 2020
New measurements of the neutron-neutron quasifree scattering cross section in neutron-deuteron breakup at an incident neutron energy of 10.0 MeV are reported. The experiment setup was optimized to evaluate the technique for determining the integrated beam-target luminosity in neutron-neutron coincidence cross-section measurements in neutron-deuteron ...
arxiv   +1 more source