Results 11 to 20 of about 2,360,825 (374)

Muscarinic receptor oligomerization [PDF]

Neuropharmacology, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers
Marsango, Sara, Ward, Richard J., Alvarez-Curto, Elisa, Milligan, Graeme   +3 more
openaire   +6 more sources

Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates. [PDF]

PLoS ONE, 2015
Cholinergic, muscarinic receptor agonists exhibit functional dopamine antagonism and muscarinic receptors have been suggested as possible future targets for the treatment of schizophrenia and drug abuse. The muscarinic ligand (5R,6R)-6-(3-butylthio-1,2,5-
Maibritt B Andersen, Carrie Hughes Croy, Ditte Dencker, Thomas Werge, Frank P Bymaster, Christian C Felder, Anders Fink-Jensen   +6 more
doaj   +1 more source

The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype.

PLoS ONE, 2020
Triple negative tumors are more aggressive than other breast cancer subtypes and there is a lack of specific therapeutic targets on them. Since muscarinic receptors have been linked to tumor progression, we investigated the effect of metronomic therapy ...
Alejandro J Español, Agustina Salem, María Di Bari, Ilaria Cristofaro, Yamila Sanchez, Ada M Tata, María E Sales   +6 more
doaj   +2 more sources

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.

Cancer Discovery, 2018
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been ...
Bernhard W. Renz, Bernhard W. Renz, Takayuki Tanaka, Takayuki Tanaka, Masaki Sunagawa, R. Takahashi, Zhengyu Jiang, M. Macchini, Z. Dantes, G. Valenti, Ruth A. White, M. Middelhoff, M. Ilmer, P. Oberstein, M. Angele, Huan Deng, Huan Deng, Y. Hayakawa, Y. Hayakawa, C. B. Westphalen, C. B. Westphalen, J. Werner, H. Remotti, M. Reichert, Yagnesh H. Tailor, K. Nagar, R. Friedman, A. Iuga, K. Olive, T. Wang   +29 more
semanticscholar   +1 more source

Brain muscarinic cholinergic receptors in Huntington's disease [PDF]

, 1992
Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects.
Agid, Y., Javoy-Agid, F., Jenner, P., Lange, Klaus W., Marsden, C. D.   +4 more
core   +1 more source

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source

Distribution and effects of the muscarinic receptor subtypes in the primary visual cortex

Frontiers in Synaptic Neuroscience, 2015
Muscarinic cholinergic receptors modulate the activity and plasticity of the visual cortex. Muscarinic receptors are divided into 5 subtypes that are not homogeneously distributed throughout the cortical layers and cells types.
Marianne eGroleau, Jun-Il eKang, Frédéric eHuppé-Gourgues, Elvire eVaucher   +3 more
doaj   +1 more source

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

Nature, 2020
After activation by an agonist, G-protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G-protein signalling and promotes receptor endocytosis 1 . Additionally, β-arrestin directly regulates many cell signalling pathways
D. Staus, Hongli Hu, M. J. Robertson, Alissa L. W. Kleinhenz, L. Wingler, W. D. Capel, Naomi R. Latorraca, R. Lefkowitz, G. Skiniotis   +8 more
semanticscholar   +1 more source

Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease [PDF]

, 1993
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects.
Jenner, P., Lange, Klaus W., Marsden, C. D., Wells, F. R.   +3 more
core   +1 more source

Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors. [PDF]

PLoS ONE, 2014
Xanomeline is an agonist endowed with functional preference for M1/M4 muscarinic acetylcholine receptors. It also exhibits both reversible and wash-resistant binding to and activation of these receptors.
Eva Šantrůčková, Vladimír Doležal, Esam E El-Fakahany, Jan Jakubík   +3 more
doaj   +1 more source