Results 11 to 20 of about 2,292,477 (411)
Modeling Recursive RNA Interference [PDF]
PLoS Computational Biology, 2008 An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo. In several published experiments, RNAi has been used to inactivate components of the RNAi pathway itself, a procedure termed recursive RNAi in this ...
A Dillin +52 more
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Random model for RNA interference yields scale free network [PDF]
, 2003 We introduce a random bit-string model of post-transcriptional genetic regulation based on sequence matching. The model spontaneously yields a scale free network with power law scaling with $ \gamma=-1$ and also exhibits log-periodic behaviour.
Balcan, Duygu, Erzan, Ayse
core +2 more sources
In silico evidence of the relationship between miRNAs and siRNAs [PDF]
arXiv, 2007 Both short interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate the repression of specific sequences of mRNA through the RNA interference pathway.
Casadio, Rita +4 more
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Time-delayed model of RNA interference [PDF]
Ecol. Compl. 30, 11-25 (2017), 2016 RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence ...
Agius +55 more
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Springer Protocols Handbooks, 2021 RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process.
Aruna Pal
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Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana [PDF]
, 2000 We investigated the potential of double-stranded RNA interference (RNAi) with gene activity in Arabidopsis thaliana. To construct transformation vectors that produce RNAs capable of duplex formation, gene-specific sequences in the sense and antisense ...
Chuang, Chiou-Fen, Meyerowitz, Elliot M.
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RNA interference approaches for treatment of HIV-1 infection. [PDF]
Genome Medicine, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
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Antiviral RNA interference in mammals [PDF]
Current Opinion in Immunology, 2018 Infection of plants and insects with RNA and DNA viruses triggers Dicer-dependent production of virus-derived small interfering RNAs (vsiRNAs), which subsequently guide specific virus clearance by RNA interference (RNAi). Consistent with a major antiviral function of RNAi, productive virus infection in these eukaryotic hosts depends on the expression ...
Shou-Wei Ding +3 more
openaire +7 more sources
Symbiont-mediated RNA interference in insects [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2016 RNA interference (RNAi) methods for insects are often limited by problems with double-stranded (ds) RNA delivery, which restricts reverse genetics studies and the development of RNAi-based biocides. We therefore delegated to insect symbiotic bacteria the
Bodger, Owen G. +7 more
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Branched RNA: A New Architecture for RNA Interference [PDF]
Journal of Nucleic Acids, 2011 Branched RNAs with two and four strands were synthesized. These structures were used to obtain branched siRNA. The branched siRNA duplexes had similar inhibitory capacity as those of unmodified siRNA duplexes, as deduced from gene silencing experiments of the TNF-α protein.
Aviñó, Anna +3 more
openaire +5 more sources