Results 21 to 30 of about 90,132 (350)

Time‐resolved multiparameter analytics on a cell‐free production platform for acyl‐CoA precursors

open access: yesAnalytical Science Advances, Volume 3, Issue 11-12, Page 289-296, December 2022., 2022
Abstract Cell‐free biosynthesis is emerging as a very attractive alternative for the production of market‐relevant molecules. The free combination of enzymes, regardless of where they are isolated from, raises the possibility to build more efficient synthetic routes but at the same time leads to higher complexity regarding the analysis of the different
Dominic Maehler   +7 more
wiley   +1 more source

NMR of $^{31}$P Nuclear Spin Singlet States in Organic Diphosphates [PDF]

open access: yes, 2021
$^{31}$P NMR and MRI are commonly used to study organophosphates that are central to cellular energy metabolism. In some molecules of interest, such as adenosine diphosphate (ADP) and nicotinamide adenine dinucleotide (NAD), pairs of coupled $^{31}$P nuclei in the diphosphate moiety should enable the creation of nuclear spin singlet states, which may ...
arxiv   +1 more source

An arsenical analogue of adenosine diphosphate [PDF]

open access: yesBiochemical Journal, 1978
An analogue of ADP was made in which the terminal phosphono-oxy group, -O-PO(OH)2, has been replaced by the arsonomethyl group, -CH2-AsO(OH)2. This compound cannot form a stable analogue of ATP because anhydrides of arsonic acids are rapidly hydrolysed, so that any enzyme that phosphorylates ADP and accepts this analogue as a substrate should release ...
Michael J. Sparkes   +2 more
openaire   +3 more sources

The Role and Molecular Mechanism of P2Y12 Receptors in the Pathogenesis of Atherosclerotic Cardiovascular Diseases

open access: yesApplied Sciences, 2021
The P2Y receptor family is a class of G protein-coupled receptors activated primarily by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP).
Lu Wang   +6 more
doaj   +1 more source

Brown adipose tissue and regulation of human body weight

open access: yesDiabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023
Abstract Background Approximately 30% of the global population is affected by obesity. Traditional non‐surgical measures for weight loss have limited efficacy and tolerability. Therefore, there is a need for novel, effective therapies. Brown adipose tissue (BAT) has been implicated in physiological energy expenditure, indicating that it could be ...
Elissa Harb   +5 more
wiley   +1 more source

Transient behaviour towards the stable limit cycle in the Selkov model of Glycolysis: A physiological disorder [PDF]

open access: yesPhysica A 567 (2021) 125684, 2020
A simplified model for the complex glycolytic process was historically proposed by Selkov. It showed the existence of stable limit cycle as an example of Poincare-Bendixson theorem. This limit cycle is nothing but the time eliminated Lissajous plot of the concentrations of Adenosine-diphosphate (ADP) and Fructose-6-phosphate (F6P) of a normal/healthy ...
arxiv   +1 more source

Adenosine diphosphate glucose and starch synthesis [PDF]

open access: yesBiochemical and Biophysical Research Communications, 1961
Received Septenber 19, 1961 In previous papers (Fekete et al., 1960; Leloir et al., 1961) an enzyme was described which catalyzes glucose transfer from uridine diphoaphate glucose (UD?G) to starch or oligosaccharides. Several synthetic nucleoside diphosphate sugars have now been tested with the same enzyme preparation.
Recondo, Eduardo F.   +1 more
openaire   +4 more sources

Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes

open access: yesHaematologica, 2012
Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods We ...
Alessandra Balduini   +8 more
doaj   +1 more source

Signaling of the Purinergic System in the Joint

open access: yesFrontiers in Pharmacology, 2020
The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body.
Carmen Corciulo   +3 more
doaj   +1 more source

Determination of Adenylate Nucleotides in Amphipod Gammarus fossarum by Ion-Pair Reverse Phase Liquid Chromatography: Possibilities of Positive Pressure Micro-Solid Phase Extraction

open access: yesSeparations, 2021
Adenine nucleotides—adenosine monophosphate, diphosphate, and triphosphate—are of utmost importance to all living organisms, where they play a critical role in the energy metabolism and are tied to allosteric regulation in various regulatory enzymes ...
Zuzana Redžović   +6 more
doaj   +1 more source

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