Results 21 to 30 of about 394,438 (273)

Clinical relevance of tumor infiltrating lymphocytes, PD-L1 expression and correlation with HPV/p16 in head and neck cancer treated with bio- or chemo-radiotherapy

OncoImmunology, 2017
To investigate the prognostic value of tumor infiltrating lymphocytes (TILs: CD8+ and FoxP3+), and PD-L1 expression in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy combined with cisplatin (CRT) or cetuximab (BRT).
Dan Ou, Julien Adam, Ingrid Garberis, Pierre Blanchard, France Nguyen, Antonin Levy, Odile Casiraghi, Philippe Gorphe, Ingrid Breuskin, François Janot, Stephane Temam, Jean-Yves Scoazec, Eric Deutsch, Yungan Tao   +13 more
doaj   +1 more source

Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response

OncoImmunology, 2020
After neoadjuvant chemoradiotherapy for esophageal adenocarcinoma, up to 29% of patients have a pathological complete response (pCR). What to do afterward is still under debate.
Andromachi Kotsafti, Melania Scarpa, Francesco Cavallin, Matteo Fassan, Roberta Salmaso, Andrea Porzionato, Luca Saadeh, Matteo Cagol, Rita Alfieri, Carlo Castoro, Massimo Rugge, Ignazio Castagliuolo, Marco Scarpa   +12 more
doaj   +1 more source

Case Report: Early presentation of hereditary angioedema symptoms in a 2-year-old boy

Frontiers in Pediatrics
Hereditary angioedema (HAE) is a rare autosomal-dominant disease that is caused by a deficiency (type I) or dysfunction (type II) of the C1 inhibitor (C1-INH) due to a mutation in the SERPING1 gene, which codes for C1-INH.
Jurate Staikuniene-Kozonis, Jurate Staikuniene-Kozonis, Juste Staikunaite, Juste Staikunaite, Edita Gasiuniene, Justina Sematonyte   +5 more
doaj   +1 more source

Deep generative selection models of T and B cell receptor repertoires with soNNia [PDF]

, 2020
Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens.
arxiv   +1 more source

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

OncoImmunology, 2018
Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen, Walter Olson, Nolan A. Wages, Brian J. Capaldo, Ileana S. Mauldin, Adela Mahmutovic, Ciara Hutchison, Cornelis J.M. Melief, Timothy N. Bullock, Victor H. Engelhard, Craig L. Slingluff   +10 more
doaj   +1 more source

Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression

Cancer Medicine, 2020
The objective of this study was to predict the value of lymphocyte subsets in cancer progression. Peripheral blood was obtained from 327 untreated patients with cancer and 158 healthy volunteers.
Ying‐Yi Wang, Na Zhou, Hong‐sheng Liu, Xiao‐Lei Gong, Rui Zhu, Xiao‐Yuan Li, Zhao Sun, Xu‐Hong Zong, Ning‐Ning Li, Chang‐Ting Meng, Chun‐Mei Bai, Tai‐Sheng Li   +11 more
doaj   +1 more source

Distribution of melanocytes in the skin of psoriasis patients

Vestnik Dermatologii i Venerologii, 2019
Psoriasis is a chronic immune-mediated inflammatory disease with predominant damage to the skin and joints. Despite fundamental studies of its pathogenesis, the cause of the development of the T-cell response has not been determined. More recently, a new
A. S. Zhukov, V. R. Khairutdinov, I. E. Belousova, A. V. Samtsov   +3 more
doaj   +1 more source

Model-based assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-cell Immune Responses [PDF]

, 2019
Activation of naive CD8 T-cells can lead to the generation of multiple effector and memory subsets. Multiple parameters associated with activation conditions are involved in generating this diversity that is associated with heterogeneous molecular contents of activated cells. Although naive cell polarisation upon antigenic stimulation and the resulting
arxiv   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer

OncoImmunology, 2019
Sipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood.
Katsunobu Hagihara, Stephen Chan, Li Zhang, David Y. Oh, Xiao X. Wei, Jeffry Simko, Lawrence Fong   +6 more
doaj   +1 more source