Results 21 to 30 of about 22,523 (167)

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size

Scientific Reports, 2018
Inhibition of succinate dehydrogenase (SDH) with malonate during reperfusion reduces infarct size in isolated mice hearts submitted to global ischemia. However, malonate has toxic effects that preclude its systemic administration in animals.
Laura Valls-Lacalle, I. Barba, E. Miró-Casas, M. Ruiz-Meana, A. Rodríguez-Sinovas, D. Garcia-Dorado   +5 more
semanticscholar   +1 more source

Focal Malonate Injection Into the Internal Capsule of Rats as a Model of Lacunar Stroke

Frontiers in Neurology, 2018
Background: Stroke is the first cause of disability in adults in western countries. Infarct of the internal capsule (IC) may be related to motor impairment and poor prognosis in stroke patients.
Carla Cirillo, Alice Le Friec, Isabelle Frisach, Robert Darmana, Lorenne Robert, Franck Desmoulin, Isabelle Loubinoux   +6 more
doaj   +1 more source

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition.

Cardiovascular Research, 2016
AIMS Previous studies demonstrated that pre-treatment with malonate, a reversible inhibitor of succinate dehydrogenase, given before ischaemia, reduces infarct size. However, it is unknown whether administration of malonate may reduce reperfusion injury.
Laura Valls-Lacalle, I. Barba, E. Miró-Casas, J. Alburquerque-Bejar, M. Ruiz-Meana, Marina Fuertes-Agudo, A. Rodríguez-Sinovas, D. Garcia-Dorado   +7 more
semanticscholar   +1 more source

Pd-Catalyzed Alkene Difunctionalization Reactions of Malonate Nucleophiles: Synthesis of Substituted Cyclopentanes via Alkene Aryl-Alkylation and Akenyl-Alkylation.

Organic Letters, 2019
The Pd-catalyzed coupling of malonate nucleophiles with alkenes bearing tethered aryl or alkenyl triflates is described. These alkene difunctionalization reactions afford malonate-substituted cyclopentanes that contain fused aryl or cycloalkenyl rings ...
Derick R White, Elsa Hinds, Evan C. Bornowski, J. Wolfe   +3 more
semanticscholar   +1 more source

Enantioselective Synthesis of Chiral Cyclopent‐2‐enones by Nickel‐Catalyzed Desymmetrization of Malonate Esters

Angewandte Chemie, 2018
The enantioselective synthesis of highly functionalized chiral cyclopent‐2‐enones by the reaction of alkynyl malonate esters with arylboronic acids is described.
S. N. Karad, H. Panchal, Christopher T. Clarke, W. Lewis, H. Lam   +4 more
semanticscholar   +1 more source

Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning

Journal of Pharmacological Sciences, 2021
Hydroxyl radical (•OH) production in the rat striatum during carbon monoxide (CO) poisoning, which inhibits complex IV, was enhanced synergistically by malonate, a mitochondrial complex II inhibitor, but not N-methyl-4-phenylpyridinium or NaCN, complex I
Fumi Kuriiwa, Masamune Kobayashi, Hajime Mizukami, Shuichi Hara   +3 more
doaj  

Supersymmetry on the Surface S_2 [PDF]

Mod.Phys.Lett. A17 (2002) 2545-2552, 2002
By using symplectic Majorana spinors as Grassmann coordinates in a superspace associated with the supersymmetric extension of the isometry group on the spherical surface S_2, it proves possible to formulate supersymmetric models on S_2 using superspace techniques.
arxiv   +1 more source

Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress

Frontiers in Pharmacology, 2012
Ever since it was shown for the first time that lactate can support neuronal function in vitro as a sole oxidative energy substrate, investigators in the field of neuroenergetics have been debating the role, if any, of this glycolytic product in cerebral
Avital eSchurr, evelyne eGozal
doaj   +1 more source

Mass Spectra of 2-Substituted Diethyl Malonate Derivatives

Molecules, 1999
Addition of Grignard derivatives to diethyl ethoxymethylene malonate generates 2-substituted diethyl malonate derivatives. This paper reports the mass spectral data for these derivatives.
Michael B. Smith, Sung Kee Chung, Tae Woo Kwon   +2 more
doaj   +1 more source

Overcoming Poor Word Embeddings with Word Definitions [PDF]

arXiv, 2021
Modern natural language understanding models depend on pretrained subword embeddings, but applications may need to reason about words that were never or rarely seen during pretraining. We show that examples that depend critically on a rarer word are more challenging for natural language inference models.
arxiv