Effects of Atomoxetine for the Treatment of Neurogenic Orthostatic Hypotension in Patients With Alpha-synucleinopathies: A Systematic Review of Randomized Controlled Trials and a Focus-Group Discussion. [PDF]
J Clin Neurol, 2023 Background and Purpose Neurogenic orthostatic hypotension (nOH) is one of the most important nonmotor symptoms in patients with α-synucleinopathies. Atomoxetine is a selective norepinephrine transporter blocker that is a treatment option for nOH.
Jung YJ, Kim A, Okamoto LE, Hong WH.
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Current Landscape of Compression Products for Treatment of Postural Orthostatic Tachycardia Syndrome and Neurogenic Orthostatic Hypotension. [PDF]
J Clin MedBackground/Objectives: Patients with postural orthostatic tachycardia syndrome (POTS) or neurogenic orthostatic hypotension (nOH) experience vertigo, confusion, and syncope.
Mitra K +6 more
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Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family. [PDF]
Clin Auton Res, 2023 Purpose Orthostatic hypotension is a common condition with heterogeneous and, in many cases, unclear underlying pathophysiology. Frequent symptoms are syncope and falls with a strong impact on daily life.
Fagius J, Klar J, Dahl N.
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Cerebral Blood Flow Dynamics in Neurogenic Orthostatic Hypotension: A Systematic Review and Meta-Analysis. [PDF]
HypertensionBACKGROUND: Neurogenic orthostatic hypotension (nOH) causes pathological falls in standing blood pressure that may or may not be symptomatic. nOH also raises the risk of poor neurological outcomes irrespective of symptom presence, possibly reflecting ...
Baker JR +7 more
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Epidural Spinal Cord Stimulation to Treat Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A New Hope? [PDF]
Mov Disord Clin Pract, 2022 Multiple system atrophy (MSA) is a neurodegenerative movement disorder clinically characterized by a combination of different degrees of parkinsonism, cerebellar ataxia, and autonomic dysfunction.
Millar Vernetti P.
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Neurogenic Orthostatic Hypotension: State of the Art and Therapeutic Strategies [PDF]
Clinical Medicine Insights: Cardiology, 2020 Neurogenic orthostatic hypotension (nOH) is a subtype of orthostatic hypotension in which patients have impaired regulation of standing blood pressure due to autonomic dysfunction. Several primary and secondary causes of this disease exist.
Dinesh K Kalra, Anvi Raina, Sumit Sohal
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Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled crossover trial. [PDF]
Clin Auton ResWe previously reported that single doses of the norepinephrine transporter inhibitor, atomoxetine, increased standing blood pressure (BP) and ameliorated symptoms in patients with neurogenic orthostatic hypotension (nOH).
Mwesigwa N +9 more
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Reduction in Pulse Pressure during Standing Can Distinguish Neurogenic Orthostatic Hypotension [PDF]
Diagnostics, 2021 Background: We investigated whether changes in the pulse pressure (PP) reduction ratio during the head-up tilt test (HUTT) can aid in distinguishing neurogenic orthostatic hypotension (OH) from non-neurogenic OH. Methods: We enrolled consecutive patients
Kyu-On Jung +3 more
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Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension [PDF]
Annals of Clinical and Translational Neurology, 2020 Objective The efficacy and safety of 1‐month atomoxetine and midodrine therapies were compared. Three‐month atomoxetine and combination therapies were investigated for additional benefits.
Jung‐Ick Byun +13 more
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Norepinephrine Reuptake Inhibition, an Emergent Treatment for Neurogenic Orthostatic Hypotension. [PDF]
HypertensionThe NET (norepinephrine transporter) is situated in the prejunctional plasma membrane of noradrenergic neurons. It is responsible for >90% of the norepinephrine uptake that is released in the autonomic neuroeffector junction.
Mwesigwa N, Shibao CA.
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