Results 21 to 30 of about 92,957 (356)
High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy
Frontiers in Pharmacology, 2017 Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes.
Sissi Dolci +15 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai +12 more
doaj +1 more source
Cells, 2023 Oligodendrocyte development is accompanied by defined changes in the state of chromatin that are brought about by chromatin remodeling complexes. Many such remodeling complexes exist, but only a few have been studied for their impact on oligodendrocytes ...
Vanessa Waldhauser +3 more
doaj +1 more source
Reaction-diffusion systems derived from kinetic theory for Multiple Sclerosis [PDF]
, 2023 We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic { theory} model describes, at the mesoscopic level, the dynamics of a high number of interacting agents. We consider both interactions among different populations of human cells and the motion of immune cells, stimulated by cytokines.
arxiv +1 more source
Altered human oligodendrocyte heterogeneity in multiple sclerosis
Nature, 2019 Oligodendrocyte pathology is increasingly implicated in neurodegenerative diseases as oligodendrocytes both myelinate and provide metabolic support to axons.
S. Jäkel +9 more
semanticscholar +1 more source
Neural Regeneration Research, 2020 Our previous studies showed that ferroptosis plays an important role in the acute and subacute stages of spinal cord injury. High intracellular iron levels and low glutathione levels make oligodendrocytes vulnerable to cell death after central nervous ...
Baoyou Fan +10 more
semanticscholar +1 more source
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Science, 2016 One size does not fit all Oligodendrocytes are best known for their ability to myelinate brain neurons, thus increasing the speed of signal transmission. Marques et al.
Sueli C Marques +22 more
semanticscholar +1 more source
Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments [PDF]
Journal of Visualized Experiments, 2020 In the central nervous system, oligodendrocytes are well-known for their role in axon myelination, that accelerates the propagation of action potentials through saltatory conduction. Moreover, an increasing number of reports suggest that oligodendrocytes interact with neurons beyond myelination, notably through the secretion of soluble factors.
Mazuir, Elisa +5 more
openaire +4 more sources
OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation
BMC Biology, 2021 Background Oligodendrocytes, responsible for axon ensheathment, are critical for central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development and performs ...
Haichao Wei +7 more
doaj +1 more source
Advances in the pathogenesis of Rett syndrome using cell models
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022 Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley +1 more source