Results 21 to 30 of about 2,292,477 (411)
CRISPR-Cas13d mediates robust RNA virus interference in plants
Genome Biology, 2019 Background CRISPR-Cas systems endow bacterial and archaeal species with adaptive immunity mechanisms to fend off invading phages and foreign genetic elements.
Ahmed Mahas, Rashid Aman, Magdy Mahfouz
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RNA virus interference via CRISPR/Cas13a system in plants
Genome Biology, 2018 Background CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA ...
Rashid Aman +7 more
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Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing [PDF]
Cell, 2001 Alla Grishok +9 more
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Microorganisms, 2021 Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.
Cassandra Koh +3 more
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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension.
New England Journal of Medicine, 2023 BACKGROUND Angiotensinogen is the sole precursor of angiotensin peptides and has a key role in the pathogenesis of hypertension. Zilebesiran, an investigational RNA interference therapeutic agent with a prolonged duration of action, inhibits hepatic ...
Akshay S. Desai +10 more
semanticscholar +1 more source
Combined VEGFR and MAPK pathway inhibition in angiosarcoma
Scientific Reports, 2021 Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited.
Michael J. Wagner +12 more
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eLife, 2023 Total RNA sequencing (RNA-seq) is an important tool in the study of mosquitoes and the RNA viruses they vector as it allows assessment of both host and viral RNA in specimens. However, there are two main constraints.
Cassandra Koh +9 more
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Strategies for Enhancing the Efficiency of RNA Interference in Insects.
Pest Management Science, 2021 Low RNA interference (RNAi) efficiency in many insect pests has significantly prevented its widespread application for insect pest management. This article provides a comprehensive review on recent research in developing various strategies for enhancing ...
K. Silver, Anastasia M W Cooper, K. Zhu
semanticscholar +1 more source