Gut Microbes, 2022 Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD) via the aberrant immune response. Some Bifidobacterial species and strains have been reported to improve AD via modulating immune-microbe interactions in ...
Zhifeng Fang +8 more
doaj +2 more sources
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
Frontiers in ImmunologyArginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of ...
Kangling Zhang +2 more
doaj +2 more sources
Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
doaj +1 more source
Tryptophan metabolism is a physiological integrator regulating circadian rhythms
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
doaj +1 more source
Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease. [PDF]
Int J Biol SciAromatic amino acid tryptophan metabolism, particularly three main metabolism pathways including kynurenine, serotonin and indole-derived pathways are under the direct or indirect modulation of host-microbiota crosstalk in human physiology.
Miao H, Zhang SJ, Wu X, Li P, Zhao YY.
europepmc +2 more sources
Tryptophan metabolism in health and disease.
Cell Metabolism, 2023 Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune
Chen Xue +10 more
semanticscholar +1 more source
TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
doaj +1 more source
Modulation of tryptophan/serotonin pathway by probiotic supplementation in human immunodeficiency virus-positive patients: preliminary results of a new study approach [PDF]
, 2017 Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals.
Cavallari, Eugenio Nelson +14 more
core +9 more sources
Metabonomic Study of the Involvement of the Intestinal Microflora in the Improvement of Iron Deficiency Anemia (IDA) by Auricularia auricula Melanin in Mice [PDF]
Shipin Kexue, 2023 Iron deficiency anemia (IDA) is a common iron deficiency disease. IDA has become one of the major public health problems worldwide. Our previous studies have shown that Auricularia auricula melanin (AAM) can alleviate IDA, but the mechanism is not clear.
WANG Yuting, LI Yuanjing, CHU Fuying, SHI Shuliang, LEI Hong, FENG Lei
doaj +1 more source
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Advancement of science, 2023 Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination ...
Dong Liu +15 more
semanticscholar +1 more source