Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression. [PDF]
, 2016 BackgroundNovel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models ...
Liu, Yin +4 more
core +2 more sources
Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy [PDF]
, 2012 Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Bland, Rosemary +2 more
core +3 more sources
Microfluidic Western blotting [PDF]
Proceedings of the National Academy of Sciences, 2012 Rapid, quantitative Western blotting is a long-sought bioanalytical goal in the life sciences. To this end, we describe a Western blotting assay conducted in a single glass microchannel under purely electronic control. The μWestern blot is comprised of multiple steps: sample enrichment, protein sizing, protein immobilization (blotting), and in situ ...
Amy E. Herr, Alex J. Hughes
openaire +3 more sources
Development and optimization of a miniaturized western blot-based screening platform to identify regulators of post-translational modifications [PDF]
, 2019 Post-translational modifications (PTMs) are fundamental traits of protein functionality and their study has been addressed using several approaches over the past years.
Gottifredi, Vanesa +2 more
core +1 more source
Microbiologia Medica, 2010 Introduction: The clinical diagnosis of syphilis is always supported by appropriate laboratory tests and the test results are interpreted with reference to the patient’s history.
Andrea Amodeo +9 more
doaj +1 more source
Evaluation of the effect of IL-36γ expression on chronic periodontitis by enhancing the MAPK and TLR4 signaling pathways: A basic research [PDF]
Journal of Dental Research, Dental Clinics, Dental Prospects, 2018 Background. Periodontitis is an infectious and inflammatory disease of the supporting tissues of the tooth caused by specific microorganisms or a group of microorganisms and, if not treated, leads to progressive degradation of the supporting tissues and ...
Amir Reza Babaloo +4 more
doaj +1 more source
Submission of Evidence on Online Violence Against Women to the UN Special Rapporteur on Violence Against Women, its Causes and Consequences, Dr Dubravka Šimonović [PDF]
, 2017 Figure S1. B3GALNT2 levels determined by W.B. and ROC curve. aâc Relative mRNA expression of B3GALNT2 in HCC tumor tissues and normal liver tissues obtained from GSE76427, GSE36376, and TCGA-LIHC datasets.
Jiangfan Zhou (5060249) +9 more
core +6 more sources
The Reactivity and Allergenic Potential of Hazelnut Peptides
Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology, 2013 The aim of this paper was to focus on proteins present in some food products, like hazelnuts and to investigate their allergenic potential. Several techniques were used to characterize these extracted proteins, with respect to their composition ...
Lavinia Florina Calinoiu +2 more
doaj +1 more source
Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]
, 2016 Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K. +2 more
core +3 more sources
Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1 [PDF]
, 1994 A gene (X33) localized on human chromosome 1 has been detected by crossreaction of its fusion protein with a monospecific antiserum directed against human vitamin-D-binding protein (hDBP; group-specific component).
Chirgwin +18 more
core +1 more source