Results 41 to 50 of about 462,461 (237)
Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells
Frontiers in Immunology, 2013 Upon engagement of their cognate class I major histocompatibility complex (MHC) ligands, receptors containing immunotyrosine-based inhibitory motifs (ITIMs) transduce signals that block cytolytic and inflammatory responses.
Thushara P Abeyweera +2 more
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Actin Engine in Immunological Synapse [PDF]
Immune Network, 2012 T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion.
Indre Piragyte, Chang-Duk Jun
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The role of the cytoskeleton at the immunological synapse [PDF]
Immunological Reviews, 2013 SummaryIt has been over 30 years since the reorganization of both the microtubule network and a ‘peculiar actin polarization’ was reported at the contact area of cytotoxic T lymphocytes interacting with target cells. Since that time, hundreds of studies have been published in an effort to elucidate the structure and function of the microtubule network ...
Karen L. Angus +2 more
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Synaptoimmunology - roles in health and disease
Molecular Brain, 2017 Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations.
Robert Nisticò +8 more
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What is the importance of the immunological synapse? [PDF]
Trends in Immunology, 2004 The immunological synapse (IS) has proved to be a stimulating concept, particularly in provoking discussion on the similarity of intercellular communication controlling disparate biological processes. Recent studies have clarified some of the underlying molecular mechanisms and functions of the IS.
Davis, Daniel M., Dustin, Michael L.
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Three-Dimensional Gradients of Cytokine Signaling between T Cells.
PLoS Computational Biology, 2015 Immune responses are regulated by diffusible mediators, the cytokines, which act at sub-nanomolar concentrations. The spatial range of cytokine communication is a crucial, yet poorly understood, functional property. Both containment of cytokine action in
Kevin Thurley +3 more
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Communication, the centrosome and the immunological synapse [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in ...
Gillian M. Griffiths +1 more
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Frontiers in Endocrinology, 2019 Based on the work in the Central Nervous System with discoveries of allosteric receptor-receptor interactions in homo- and heteroreceptor complexes representing a major integrative mechanism in synapses and extrasynaptic regions, it is proposed that a ...
Dasiel O. Borroto-Escuela +3 more
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ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells [PDF]
Journal of Innovative Optical Health Sciences, 2018 T-cell activation requires the formation of the immunological synapse (IS) between a T-cell and an antigen-presenting cell (APC) to control the development of the adaptive immune response. However, calcium release, an initial signal of T-cell activation,
Yuanzhen Suo +7 more
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What Counts in the Immunological Synapse? [PDF]
Molecular Cell, 2014 Molecular interactions at the interface between helper T cells and antigen-presenting B cells govern the ability to produce specific antibodies, which is a central event in protective immunity generated by natural infection or man-made vaccines. In order for a T cell to deliver effective help to a B cell and guide affinity maturation, it needs to ...
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