Results 1 to 10 of about 256,510 (161)
Application of Peptides Containing the Cleavage Sequence of Pro-TNFα in Assessing TACE Activity of Whole Cells [PDF]
Biological Chemistry, 2002 Tumor necrosis factor-α (TNFα) is presumably shed from cell membranes by TNFα-cleaving enzyme (TACE). The peptides SPLAQAVRSSSR and Dabcyl-LAQAVRSSSR-Edans, each encompassing the cleavage sequence of pro-TNFα recognized by TACE, were applied to intact umbilical vein endothelium (HUVEC), peripheral blood leukocytes (PBL) and the mast cell line HMC-1,
Becker, Bernhard F. +3 more
openaire +5 more sources
Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. [PDF]
, 2014 Inflammatory response and cell death in hepatocytes are hallmarks of chronic liver disease, and, therefore, can be effective therapeutic targets. Neurotropin® (NTP) is a drug widely used in Japan and China to treat chronic pain.
Liang, Shuang +6 more
core +21 more sources
Analysis of hematological parameters in rheumatoid arthritis patients receiving biological therapy
EXCLI Journal : Experimental and Clinical Sciences, 2022 Administration of biological therapy (BT) in rheumatoid arthritis (RA) patients is often associated with hematological complications, which result in switching among therapies.
Jana Pereckova +5 more
doaj +1 more source
Ankylosing spondylitis and multiple sclerosis: a surprising parallel [PDF]
Romanian Journal of Neurology, 2014 Ankylosing Spondylitis (AS) and Multiple Sclerosis (MS) are two different chronic autoimmune and inflammatory diseases, one rheumatic and the other one neurological, apparently without any connection between them.
Iulia Georgiana Stamate +3 more
doaj +1 more source
CDKI-73 Is a Novel Pharmacological Inhibitor of Rab11 Cargo Delivery and Innate Immune Secretion
Cells, 2020 Innate immunity is critical for host defence against pathogen and environmental challenge and this involves the production and secretion of immune mediators, such as antimicrobial peptides and pro-inflammatory cytokines.
Alexandra Sorvina +6 more
doaj +1 more source
Медицинская иммунология, 2021 Traumatic brain injury is the most common cause of death and disability in young people including sport athletes and soldiers, people under 45 years of age in the industrialized countries, representing a growing health problem in developing countries, as
E. A. Korneva +4 more
doaj +1 more source
Biological Therapy During COVID-19
Вопросы современной педиатрии, 2020 There is crucial question on further therapeutic tactics for the management of such patients (within the severe epidemiological situation caused by the pandemic of new coronavirus SARS-CoV-2) due to widespread application of genetically engineered ...
Leyla S. Namazova-Baranova +2 more
doaj +1 more source
Amyloid Beta, TNFα and FAIM-L; Approaching New Therapeutic Strategies for AD [PDF]
Frontiers in Neurology, 2014 ALZHEIMER’S DISEASE AND AMYLOID BETA Defining characteristics of Alzheimer’s disease (AD) are memory defects, synaptic alterations, presence of neuroinflammatory mediators, and a progressive neurodegeneration. One of the histopathological hallmarks of the disease is the presence of amyloid beta (Aβ) plaques; however, it seems that soluble oligomers ...
Carriba, Paulina, Comella, Joan X.
openaire +2 more sources
The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus
Indonesian Journal of Tropical and Infectious Disease, 2010 Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial.
Soegeng Soegijanto +3 more
doaj +1 more source
Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFα release [PDF]
Frontiers in Cell and Developmental Biology, 2014 The activation of p38 MAPK in myogenic precursor cells (MPCs) is a key signal for their exit of cell cycle and entry of the myogenic differentiation program. Therefore, identification of the signaling mechanism that activates p38 MAPK during this process is important for the understanding of the regulatory mechanism of muscle regeneration. This article
Li, Yi-Ping, Niu, Airu, Wen, Yefei
openaire +3 more sources