Results 91 to 100 of about 1,026 (107)

Preclinical PET Studies of [11C]UCB-J Binding in Minipig Brain

Molecular Imaging and Biology, 2020
Purpose: Loss of neuronal synapse function is associated with a number of brain disorders. The [11C]UCB-J positron emission tomography (PET) tracer allows for in vivo examination of synaptic density, as it binds to synaptic vesicle glycoprotein 2A (SV2A) expressed in presynaptic terminals.
Majken Borup Thomsen, Anna Christina Schacht, Aage Kristian Olsen Alstrup, Jan Jacobsen, Thea Pinholt Lillethorup, Simone Larsen Bærentzen, Ove Noer, Dariusz Orlowski, Betina Elfving, Heidi Kaastrup Müller, David J. Brooks, Anne M. Landau   +11 more
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Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue

Molecular Imaging and Biology, 2019
The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([11C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) parametric maps using white matter (centrum semi-ovale-SO) as reference tissue.Ten healthy volunteers (8 M/2F; age 27.6 ± 10.0 years) underwent a 90-min dynamic [11C]UCB ...
Nathalie Mertens, Ralph Paul Maguire, Kim Serdons, Brigitte Lacroix, Joel Mercier, David Sciberras, Koen Van Laere, Michel Koole   +7 more
openaire   +2 more sources

226  Reduced synaptic density in progressive supranuclear palsy and corticobasal syndrome, revealed by [11C]UCB-J PET

Journal of Neurology, Neurosurgery & Psychiatry, 2022
Synaptic loss is prominent in several human neurodegenerative diseases. We tested the hypothesis that synaptic density is reduced by the primary tauopathies of progressive supranuclear palsy (PSP) and cor- ticobasal syndrome (CBS). Thirty-three participants (10 CBS, 10 PSP, and thirteen age-/sex-/education- matched controls) underwent clinical and ...
Negin Holland, P Simon Jones, George Savulich, Young T Hong, Tim Fryer, Roido Manavaki, Selena Milicevic-Sephton, Franklin I Aigbirhio, John O’Brien, James B Rowe   +9 more
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11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults

Molecular Psychiatry
The neural bases of autism are poorly understood at the molecular level, but evidence from animal models, genetics, post-mortem studies, and single-gene disorders implicate synaptopathology. Here, we use positron emission tomography (PET) to assess the density of synapses with synaptic vesicle glycoprotein 2A (SV2A) in autistic adults using 11C-UCB-J ...
David Matuskey, Yanghong Yang, Mika Naganawa, Sheida Koohsari, Takuya Toyonaga, Paul Gravel, Brian Pittman, Kristen Torres, Lauren Pisani, Caroline Finn, Sophie Cramer-Benjamin, Nicole Herman, Lindsey H. Rosenthal, Cassandra J. Franke, Bridget M. Walicki, Irina Esterlis, Patrick Skosnik, Rajiv Radhakrishnan, Julie M. Wolf, Nabeel Nabulsi, Jim Ropchan, Yiyun Huang, Richard E. Carson, Adam J. Naples, James C. McPartland   +24 more
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A new phenylstannyl precursor for synthesizing [11C]UCB-J

Nuclear Medicine and Biology, 2023
Wakana Mori, Nobuki Nengaki, Hideki Ishii, Katsushi Kumata, Masayuki Fujinaga, Ming-Rong Zhang   +5 more
openaire   +1 more source

Long term experience in [11C]UCB-J production in Turku PET Centre

Nuclear Medicine and Biology, 2022
Anna Krzyczmonik, Saara Wahlroos, Semi Helin, Anna Kirjavainen, Olof Solin   +4 more
openaire   +1 more source

Spontaneous brain activity and synaptic density in schizophrenia: a combined [11C]UCB-J PET and fMRI study

Abstract Schizophrenia is associated with altered Amplitude of Low Frequency Fluctuations (ALFF), a functional Magnetic Resonance Imaging (fMRI) measure of spontaneous brain activity at rest. ALFF in healthy controls has been linked with presynaptic density levels measured by [11C]UCB-J positron emission tomography (PET).
Ekaterina Shatalina, Ellis Chika Onwordi, Thomas Whitehurst, Alexander Whittington, Ayla Mansur, Atheeshaan Arumuham, Tiago Reis Marques, Roger N. Gunn, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall, Oliver D Howes   +11 more
openaire   +1 more source

Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023
For some positron emission tomography studies, radiotracer is administered as bolus plus continuous infusion (B/I) to achieve a state of equilibrium. This approach can reduce scanning time and simplify data analysis; however, the method must be validated and optimized for each tracer. This study aimed to validate a B/I method for in vivo quantification
Ruth H, Asch, Mika, Naganawa, Nabeel, Nabulsi, Yiyun, Huan, Irina, Esterlis, Richard E, Carson   +5 more
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A Practical Production of Clinical Interesting Radiotracer [11C]UCB-J

Nuclear Medicine and Biology, 2023
Hari Akula, Bao Hu, Gino Giacoio, Yiu-Fung Mui, Qing Feng, Mark Slifstein, Ramin Parsey, Wenchao Qu   +7 more
openaire   +1 more source

Quantitative monitoring of ketamine’s impact on synaptic density using 11C-UCB-J PET imaging in the corticosterone mouse model of anxiety/depression

Molecular Psychiatry
Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic connections observed in depression. PET imaging using 11C-UCB-J, a radiotracer targeting the synaptic vesicle protein 2 A (SV2A), was investigated as a translational method to monitor ketamine-induced changes
Corvo, Cassandre, Goutal, Sébastien, Mendez-David, Indira, Leterrier, Sarah, Caille, Fabien, Saba, Wadad, Colle, Romain, Corruble, Emmanuelle, Lebon, Vincent, Bottlaender, Michel, Leroy, Claire, J. David, Denis, Tournier, Nicolas   +12 more
openaire   +2 more sources