Results 11 to 20 of about 2,347 (126)

6-shogaol is a potential treatment for Head and Neck Squamous Cell Carcinoma. [PDF]

Int J Med Sci, 2023
Objective: Natural products in diet have shown a potential role in the prevention and treatment of cancer. Ginger (Zingiber officinale Roscoe) is a great candidate because of its properties of anti-inflammatory, antioxidant, and anti-cancer, but little is known about its effect on head and neck cancer.
Hsu CM, Su HC, Yang MY, Tsai YT, Tsai MS, Yang YH, Wu CY, Chang SF.   +7 more
europepmc   +3 more sources

Metabolism of [6]-Shogaol in Mice and in Cancer Cells [PDF]

Drug Metabolism and Disposition, 2012
Ginger has received extensive attention because of its antioxidant, anti-inflammatory, and antitumor activities. However, the metabolic fate of its major components is still unclear. In the present study, the metabolism of [6]-shogaol, one of the major active components in ginger, was examined for the first time in mice and in cancer cells.
Huadong, Chen, Lishuang, Lv, Dominique, Soroka, Renaud F, Warin, Tiffany A, Parks, Yuhui, Hu, Yingdong, Zhu, Xiaoxin, Chen, Shengmin, Sang   +8 more
openaire   +3 more sources

Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice [PDF]

Chemical Research in Toxicology, 2013
Shogaols, a series of major constituents in dried ginger (Zingiber officinale), show high anticancer potencies. Previously, we reported that a major metabolite resulting from the mercapturic acid pathway, 5-cysteinyl-[6]-shogaol (M2), showed comparable growth inhibitory effects toward cancer cells to [6]-shogaol (6S).
Huadong, Chen, Dominique N, Soroka, Yingdong, Zhu, Yuhui, Hu, Xiaoxin, Chen, Shengmin, Sang   +5 more
openaire   +2 more sources

Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives. [PDF]

Molecules, 2022
Twenty newly synthesized derivatives of [6]-shogaol (4) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead compound.
Phaosiri C, Yenjai C, Senawong T, Senawong G, Saenglee S, Somsakeesit LO, Kumboonma P.   +6 more
europepmc   +4 more sources

Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis. [PDF]

Eur Oral Res, 2023
(6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model.Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group
Bezirci D, Karsiyaka Hendek M, Ozcan G, Kul O, Anteplioglu T, Olgun E.   +5 more
europepmc   +6 more sources

EVALUATION OF ANTIDEPRESSANT EFFECT OF 6-SHOGAOL IN ANIMAL MODELS

Current Research in Pharmaceutical Sciences, 2022
The objective of the study was therefore to evaluate the role of 6-shogaol in the antidepressant effect Zingiber officinale using two different animal models viz., tail suspension test and forced swim test. Ginger rhizomes were extracted using water-methanol (80/20) as the solvent using maceration and 6-shogaol was isolated from the extract using ...
PAYAL RAHANGDALE, DEEPAK KUMAR BASEDIYA, VIVEK THAKUR, BALKRISHNA DUBEY   +3 more
openaire   +1 more source

6-shogaol suppresses oxidative damage in L6 muscle cells [PDF]

Applied Biological Chemistry, 2020
AbstractGinger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured.
Jinyoung Hur, Yeonmi Lee, Chang Jun Lee, Ho-Young Park, Sang Yoon Choi   +4 more
openaire   +1 more source

Coadministration of 6-Shogaol and Levodopa Alleviates Parkinson's Disease-Related Pathology in Mice. [PDF]

Biomol Ther (Seoul)
Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in the nigrostriatal pathway, leading to motor and non-motor dysfunctions, such as depression, olfactory dysfunction, and memory impairment. Although levodopa (L-dopa) has been the gold standard PD treatment for decades, it only relieves motor symptoms ...
Kim JH, Kim JS, Ju IG, Huh E, Choi Y, Lee S, Cho JY, Park BY, Oh MS.   +8 more
europepmc   +3 more sources

Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells [PDF]

Pharmaceuticals, 2019
Ginger is a plant that is native to southern China. In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibits the greatest potential antitumor capacity. However, the molecular mechanism through which 6-shogaol exerts its effects has not yet been elucidated. In this study, the effect
Angie C. Romero-Arias, Luis G. Sequeda-Castañeda, Andres F. Aristizábal-Pachón, Ludis Morales   +3 more
openaire   +3 more sources

Inhibition of Homodimerization of Toll-like Receptor 4 by 6-Shogaol

Molecules and Cells, 2009
Toll-like receptors (TLRs) play a critical role in sensing microbial components and inducing innate immune and inflammatory responses by recognizing invading microbial pathogens. Lipopolysaccharide-induced dimerization of TLR4 is required for the activation of downstream signaling pathways including nuclear factor-kappa B (NF-kappaB).
Sang-Il, Ahn, Jun-Kyung, Lee, Hyung-Sun, Youn   +2 more
openaire   +2 more sources