Results 21 to 30 of about 2,347 (126)

Pharmacological studies on ginger. IV Effect of (6)-shogaol on the arachidonic cascade.

Folia Pharmacologica Japonica, 1986
(6)-Shogaol, a pungent component of ginger, which is contained in semi-dried ginger but is rarely found in fresh ginger inhibited carrageenin-induced swelling of hind paw in rats and arachidonic acid (AA)-induced platelet aggregation in rabbits. Moreover, (6)-shogaol prevented prostaglandin I2 (PGI2) release from the aorta of rats when tested as an ...
M, Suekawa, K, Yuasa, M, Isono, H, Sone, Y, Ikeya, I, Sakakibara, M, Aburada, E, Hosoya   +7 more
openaire   +4 more sources

Research Progress on Antitumor Mechanism of 6-Shogaol

Shipin gongye ke-ji, 2023
The incidence and mortality of cancer are increasing year by year, which seriously threatens human health. 6-Shogaol, as one of the main active components in ginger, has become the focus of attention in recent years due to its advantages of safety and low toxicity.
Zhuan WANG, Hongliu HU, Qifeng CHEN, Jie ZHOU, Zhenzhen REN, Lihe JIANG   +5 more
openaire   +1 more source

Effects of ginger constituent 6‐shogaol on gastroesophageal vagal afferent C‐fibers [PDF]

Neurogastroenterology & Motility, 2019
AbstractBackgroundGinger has been used as an herbal medicine worldwide to relieve nausea/vomiting and gastrointestinal discomfort, but the cellular and molecular mechanisms of its neuronal action remain unclear. The present study aimed to determine the effects of ginger constituent 6‐shogaol on gastroesophageal vagal nodose C‐fibers ...
Yongming Huang, Mayur J. Patil, Mingwei Yu, Peter Liptak, Bradley J. Undem, Xinzhong Dong, Guobin Wang, Shaoyong Yu   +7 more
openaire   +2 more sources

Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study.

European review for medical and pharmacological sciences, 2022
Acetaminophen (APAP) is one of the most commonly used analgesics and antipyretics. It causes serious liver damage when taken in large quantities by adults or children. Also, 6-shogaol is an active compound obtained from ginger with anti-inflammatory and antioxidant properties.
GÜNAY, NURULLAH, Tekin, Y., Cumaoğlu, B., Cumaoğlu, M. Oğuz   +3 more
openaire   +5 more sources

Targeted Metabolomics Reveals Tissue‐Specific Accumulation and Translocation of Bioactive Compounds in Ginger During Growth

Food Frontiers, Volume 7, Issue 5, September 2026.
Targeted UHPLC–MS/MS methods were established to quantify 32 bioactive compounds in ginger leaves, stems, and rhizomes during growth. Distinct tissue‐specific accumulation and translocation patterns were observed, and aminoacyl‐tRNA biosynthesis was identified as the most active pathway in ginger development.
Yinfeng Zhao, Qin Wang, Jiguang Zhang, Xiuhua Liu, Yixuan Jiang, Qingzhi Li, Chunhua Shang, Min Lin, Rui Weng, Jing Qiu, Yongzhong Qian   +10 more
wiley   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

MedComm, Volume 7, Issue 9, September 2026.
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu   +5 more
wiley   +1 more source

[6]-Shogaol Induces Apoptosis of Murine Bladder Cancer Cells

Cellular Physiology and Biochemistry
Background/Aims: Bladder cancer is considered one of the most aggressive neoplasms due to its recurrence and progression profile, and even with the improvement in diagnosis and treatment methods, the mortality rate has not shown a declining trend in recent decades.
Diana Gabriela, Nina Nina, Thaiane Alcarde, Robeldo, Almada da, Silva, Vitória Shiévila, Dos Santos Gonçalves, Ricardo Carneiro, Borra, Fernanda de Freitas, Anibal   +5 more
openaire   +2 more sources

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

Customer‐Oriented Development and Characterization of Spice‐Enriched Extruded Breakfast Cereal From Rice Bran and Unripe Banana Flour

Journal of Food Science, Volume 91, Issue 9, September 2026.
ABSTRACT Developing functional breakfast cereals that are both nutritionally enhanced and consumer‐acceptable remains a key challenge for product innovation. This study developed a consumer‐oriented, spice‐enriched extruded breakfast cereal formulated by partially substituting corn grits with rice bran and unripe banana flour, with product optimization
Zaki Muhammad Husyemi Rafsanjani, Slamet Budijanto, Vallerina Armetha, Azis Boing Sitanggang   +3 more
wiley   +1 more source