Results 131 to 140 of about 88,586 (196)

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Comparing and combining xevinapant with ATR and PARP inhibition for the radiosensitization of HPV-negative HNSCC cells. [PDF]

Sci Rep
Roehrle J, Perugachi-Heinsohn A, Gatzemeier F, Christiansen S, Petersen C, Rothkamm K, Betz C, Kriegs M, Zech HB, Rieckmann T.   +9 more
europepmc   +1 more source

Self‐Sustaining Piezozyme Platform for Antifouling via Mechanically Triggered Enzymatic Cascade

Advanced Science, EarlyView.
Wave‐powered CeO2/g‐C3N4 piezozyme coating converts ocean motion into an enzymatic H2O2‐to‐ROS cascade, realizing 180‐day eco‐friendly marine antifouling. ABSTRACT Harnessing ubiquitous mechanical energy for catalytic activation offers an emerging pathway toward self‐sustaining environmental protection systems.
Jingyu Wang, Yanjun Yu, Rongxin Su, Jiangjiexing Wu   +3 more
wiley   +1 more source

Frequency and Age-Related Changes in Corneal Astigmatism in Cataract Surgery Candidates at a Training Hospital in Turkey. [PDF]

Medicina (Kaunas)
Yilmaz AC, Cakir Ince BA, Ayyildiz O, Mutlu FM.   +3 more
europepmc   +1 more source

Modulating Local Electronic Structure via Cluster Engineering on Cobalt Phosphide for Efficient Water/Seawater Splitting

Advanced Science, EarlyView.
The heterostructure benefits from the high dispersion of FeOx nanoclusters on the porous CoxP substrate, while the interfacial bonds Fe‐O‐Co enhance charge transport and redistribution, resulting in excellent oxygen evolution reaction performance and strong potential for practical applications.
Cheng Gong, Fengying Pan, Pengpeng Zhang, Yuhan Xie, Yaojie Lei, Xiaobo Zheng, Dinushi Munasinghe Mudiyanselage, Hong Gao, Jinqiang Zhang, Yufei Zhao, Guoxiu Wang, Hao Liu   +11 more
wiley   +1 more source

Infrared spectral data of natural and man-made textile fibres for material identification and classification. [PDF]

Data Brief
Parkar R, Jain A, Prendergast-Miller M, Stanton T, Sheridan KJ, Gallidabino MD.   +5 more
europepmc   +1 more source

Clickable Microgel Inks Enable Spatioselective, Multi‐Stimuli Programmable Assembly of Materials

Advanced Science, EarlyView.
Clickable microgel inks enable direct ink writing of hydrogel architectures with intrinsic spatioselective and programmable multi‐responsiveness. By combining pH‐responsive and temperature‐responsive microgel building blocks through Diels‐Alder interparticle crosslinking, the assemblies exhibit controllable swelling and shape changes.
Junho Moon, Frank Gardea, Madeline A. Morales, Svetlana Sukhishvili   +3 more
wiley   +1 more source