Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase [PDF]
Molecular Pharmaceutics, 2021 Recruitment and activation of the ataxia telangiectasia mutated (ATM) kinase regulate multiple cell-cycle checkpoints relevant to complex biological events like DNA damage repair and apoptosis. Molecularly specific readouts of ATM using protein assays, fluorescence, or radiolabeling have advanced significantly over the past few years.
Cien Huang +3 more
openaire +2 more sources
Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia
Antioxidants, 2022 The ataxia-telangiectasia mutated (ATM) protein kinase is, as the name implies, mutated in the human genetic disorder ataxia-telangiectasia (A-T). This protein has its “finger in many pies”, being responsible for the phosphorylation of many thousands of ...
Goutham Narayanan Subramanian +4 more
doaj +1 more source
ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels
Frontiers in Cell and Developmental Biology, 2022 Ataxia-telangiectasia mutated (ATM) is one of the three main apical kinases at the crux of DNA damage response and repair in mammalian cells. ATM activates a cascade of downstream effector proteins to regulate DNA repair and cell cycle checkpoints in ...
Pragya Shah +8 more
doaj +1 more source
MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
PLoS ONE, 2022 Ataxia Telangiectasia mutated and RAD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA double-strand breaks (DSBs).
Katrina Montales +3 more
doaj +1 more source
What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence [PDF]
E3S Web of Conferences, 2021 A mitotic cell that rests in permanent cell cycle arrest without the ability to divide is considered as a senescent cell. Cellular senescence is essential to limit the function of cells with heavy DNA damages.
Jia Hanyi
doaj +1 more source
Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A [PDF]
The EMBO Journal, 2004 Ionizing radiation induces autophosphorylation of the ataxia-telangiectasia mutated (ATM) protein kinase on serine 1981; however, the precise mechanisms that regulate ATM activation are not fully understood. Here, we show that the protein phosphatase inhibitor okadaic acid (OA) induces autophosphorylation of ATM on serine 1981 in unirradiated cells at ...
Goodarzi, Aaron A +7 more
openaire +5 more sources
Immunoassay to Measure Ataxia-Telangiectasia Mutated Protein in Cellular Lysates [PDF]
Clinical Chemistry, 2004 AbstractBackground: Ataxia-telangiectasia (A-T) is a neurologic disorder caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A clinical diagnosis of A-T is confirmed by radiosensitivity testing and immunoblotting for ATM protein. Because both of these tests have long turnaround times (≥3 months), we developed a rapid immunoassay to ...
Anthony W, Butch +3 more
openaire +2 more sources
Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. [PDF]
PLoS ONE, 2016 Several stressors are known to influence epithelial tight junction (TJ) integrity, but the association between DNA damage and TJ integrity remains unclear.
Akihiro Watari +3 more
doaj +1 more source
The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration [PDF]
Journal of Virology, 2005 ABSTRACT Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the host DNA and insertion of the viral DNA, forming an integration intermediate that contains two gaps, each with a viral 5 ...
Jason L, Dehart +7 more
openaire +2 more sources
Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3 [PDF]
Journal of Biological Chemistry, 2003 Phosphorylation at Ser(727) is known to be required for complete activation of STAT3 by diverse stimuli including UV irradiation, but the kinase(s) responsible for phosphorylating STAT3 (Ser(727)) is still not well discerned. In the present study, we observed that activation of ATM is required for a UVA-stimulated increase in Ser(727) phosphorylation ...
Yiguo, Zhang +5 more
openaire +2 more sources