Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia
Antioxidants, 2022 The ataxia-telangiectasia mutated (ATM) protein kinase is, as the name implies, mutated in the human genetic disorder ataxia-telangiectasia (A-T). This protein has its “finger in many pies”, being responsible for the phosphorylation of many thousands of ...
Goutham Narayanan Subramanian +4 more
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ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels
Frontiers in Cell and Developmental Biology, 2022 Ataxia-telangiectasia mutated (ATM) is one of the three main apical kinases at the crux of DNA damage response and repair in mammalian cells. ATM activates a cascade of downstream effector proteins to regulate DNA repair and cell cycle checkpoints in ...
Pragya Shah +8 more
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MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
PLoS ONE, 2022 Ataxia Telangiectasia mutated and RAD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA double-strand breaks (DSBs).
Katrina Montales +3 more
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What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence [PDF]
E3S Web of Conferences, 2021 A mitotic cell that rests in permanent cell cycle arrest without the ability to divide is considered as a senescent cell. Cellular senescence is essential to limit the function of cells with heavy DNA damages.
Jia Hanyi
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Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. [PDF]
PLoS ONE, 2016 Several stressors are known to influence epithelial tight junction (TJ) integrity, but the association between DNA damage and TJ integrity remains unclear.
Akihiro Watari +3 more
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c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage. [PDF]
PLoS ONE, 2018 All cellular processes, including those involved in normal cell metabolism to those responsible for cell proliferation or death, are finely controlled by cell signaling pathways, whose core proteins constitute the family of phosphatidylinositol 3-kinase ...
Raíssa Bernardes da Silva +3 more
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The versatile functions of ATM kinase
Biomedical Journal, 2014 Ataxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxia-telangiectasia, plays an essential role in the maintenance of genome stability.
Rebecca J Boohaker, Bo Xu
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ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. [PDF]
PLoS ONE, 2010 Chromosome translocations induced by DNA damaging agents, such as ionizing radiation and certain chemotherapies, alter genetic information resulting in malignant transformation. Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a DNA
Jiying Sun +10 more
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Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair
Life Science Alliance, 2018 This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Noriko Hosoya +2 more
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