Results 41 to 50 of about 1,665,599 (197)

Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma

Applied Immunohistochemistry & Molecular Morphology, 2020
Ataxia-telangiectasia mutated (ATM), a key activator of DNA damage response mechanisms, represents a potential biomarker for targeted gastric carcinoma therapies. A phase II study (Study 39; NCT01063517) designed to investigate the combination olaparib plus paclitaxel in patients with recurrent or metastatic gastric cancer did not meet its primary ...
Miller, Rachel M., Nworu, Chinedu, McKee, Laurel, Balcerzak, Denis, Pham, Linh, Pugh, Judith, Liu, Yu-Zhen, Gustafson, Heather, Marwah, Ekta, Lamb, Tiffany, Clements, June   +10 more
openaire   +3 more sources

Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis

Chinese Medical Journal, 2015
Background: Caffeine suppresses ataxia telangiectasia and Rad3 related and ataxia telangiectasia mutated (ATM) activities; ATM is the major kinase for DNA damage detection.
Zhe-Wei Zhang, Jing Xiao, Wei Luo, Bo-Han Wang, Ji-Min Chen   +4 more
doaj   +1 more source

Targeting ATM pathway for therapeutic intervention in cancer [PDF]

BioDiscovery, 2012
The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Hilal S Khalil, Hemanth Tummala, Stoyan Chakarov, Nikolai Zhelev, David P. Lane   +4 more
doaj   +3 more sources

Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer [PDF]

Clinical Colorectal Cancer, 2018
Loss of ataxia telangiectasia mutated (ATM), a key protein regulating DNA repair signaling, has been suggested to increase sensitivity to DNA damaging agents. We conducted a study analyzing the loss of ATM protein expression in colorectal cancer and correlated this with clinical outcomes.The clinical outcomes data and tumor samples from metastatic ...
Raghav Sundar, Susana Miranda, Daniel Nava Rodrigues, Maxime Chénard-Poirier, David Dolling, Matthew Clarke, Ines Figueiredo, Claudia Bertan, Wei Yuan, Ana Ferreira, Rossitza Chistova, Gunther Boysen, Desamparados Roda Perez, Nina Tunariu, Joaquin Mateo, Andrew Wotherspoon, Ian Chau, David Cunningham, Nicola Valeri, Suzanne Carreira, Johann de Bono   +20 more
openaire   +3 more sources

Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. [PDF]

PLoS ONE, 2013
Although structurally and biochemically similar to the cellular prion (PrP(C)), doppel (Dpl) is unique in its biological functions. There are no reports about any neurodegenerative diseases induced by Dpl.
Kefeng Qin, Tianbing Ding, Yi Xiao, Wenyu Ma, Zhen Wang, Jimin Gao, Lili Zhao   +6 more
doaj   +1 more source

Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats [PDF]

Medical Science Monitor, 2017
BACKGROUND Previous studies revealed physiological and pathogenetic similarity between vascular smooth muscles cells with severe pulmonary arterial hypertension and tumors. The DNA damage response was found in both pulmonary arterial hypertension (PAH) cells and tumors. The ataxia-telangiectasia mutated proteins (ATM) pathway is considered an important
Hu, Fan, Liu, Caijun, Liu, Hanmin, Xie, Liang, Yu, Li   +4 more
openaire   +2 more sources

Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress‐Induced Metabolic Recycling

Oxidative Medicine and Cellular Longevity, 2021
Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis. Best known for its role as a transducer of DNA damage repair, the activity of ATM in the cytosol is enjoying increasing attention, where it plays a central role in general ...
Marguerite Blignaut, Sarah Harries, Amanda Lochner, Barbara Huisamen   +3 more
openaire   +3 more sources

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants [PDF]

, 2015
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to target
Davies, Nicholas J, Wei, Wenbin, Payne, D.T., Stankovic, Tatjana, Stewart, Grant S.; id_orcid, Weston, V. J., Taylor, A Malcolm R, Michael McMahon, Coles, Steve J., Fossey, J.S., Daniel T. Payne, Hayes, J.D., Stankovic, T., Stankovic, Tatjana; id_orcid, Payne, Daniel T., Oldreive, C. E., Darley, Richard L., John D. Hayes, Agathanggelou, A., Wei, W., Coles, Steve J, Richard L. Darley, Tatjana Stankovic, Steve J. Coles, Hayes, John D., Payne, D. T., Stewart, G., Tracey Perry, Taylor, A. M. R., Moss, Paul; id_orcid, Darley, R. L., Oldreive, Ceri E., Pratt, Guy, Paul S. Hole, Coles, Steven, Moss, Paul, Darley, R.L., Weston, Victoria J, Oldreive, C.E., Victoria J. Weston, David Oscier, Pratt, G., Stewart, Grant, Weston, V.J., Hayes, John D, A. Malcolm R. Taylor, McMahon, M., Agathanggelou, Angelo, Moss, P., Darley, Richard L, Oscier, David, Parry, Helen, Hole, Paul S., Wenbin Wei, Hole, Paul S, Anna Skowronska, Hole, P.S., Weston, Victoria J., Stewart, Grant S, Taylor, A. Malcolm R., Fossey, John S, Darley, Richard Lawrence, Oldreive, Ceri E, Hayes, J. D., Hole, Paul Spencer, Perry, T., Taylor, A. Malcolm R, Payne, Daniel T, Skowronska, Anna, Nicholas J. Davies, Davies, Nicholas J., Perry, Tracey, Helen Parry, Hole, P. S., Wei, Wenbin; id_orcid, Parry, H., Taylor, M., Guy Pratt, Parry, Helen; id_orcid, McMahon, Michael, Davies, N. J., Skowronska, A., Oscier, D., Fossey, John S., John S. Fossey, Davies, N.J., Angelo Agathanggelou, Coles, S. J., Paul Moss, Grant S. Stewart, Fossey, J. S., Ceri E. Oldreive   +91 more
core   +2 more sources

Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

Cell Reports, 2012
Ataxia telangiectasia mutated (ATM) protein kinase activation by DNA double-strand breaks (DSBs) requires the Mre11-Rad50-NBS1 (MRN) complex, whereas ATM interactor (ATMIN) protein is required for ATM signaling induced by changes in chromatin structure ...
Tianyi Zhang, Kay Penicud, Christopher Bruhn, Joanna I. Loizou, Nnennaya Kanu, Zhao-Qi Wang, Axel Behrens   +6 more
doaj   +1 more source

The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations [PDF]

DNA Repair, 2019
The ataxia telangiectasia-mutated and Rad3-related (ATR) serine/threonine kinase plays a central role in the repair of replication-associated DNA damage, the maintenance of S and G2/M-phase genomic stability, and the promotion of faithful mitotic chromosomal segregation.
Jie Chen, Xinggui Shen, Sibile Pardue, Andrew T. Meram, Saranya Rajendran, Ghali E. Ghali, Christopher G. Kevil, Rodney E. Shackelford   +7 more
openaire   +2 more sources