Results 21 to 30 of about 20,819 (199)

514 ATAXIA TELANGIECTASIA MUTATED PROTEIN MODULATES GLUCOSE AND LIPID METABOLISM IN THE HEART

European Heart Journal Supplements, 2022
Abstract Background Ataxia Telangiectasia Mutated (ATM) protein kinase is the major sensor of DNA damage response (DDR) and oxidative stress, variously implicated in cellular metabolism. Previous studies on ATM functions in the heart have produced conflicting results.
Paolillo, Roberta, D ́apice, Stefania, Caterino, Marianna, Pezone, Antonio, Iole, Danila, Polese, Pina, Pentella, Tommaso, Ruoppolo, Margherita, Enrico, Avvedimento Vittorio, Esposito, Giovanni, Perrino, Cinzia   +10 more
openaire   +2 more sources

Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. [PDF]

PLoS Genetics, 2015
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an untreatable autosomal dominant neurodegenerative disease, and the most common such inherited ataxia worldwide.
Rui Gao, Yongping Liu, Anabela Silva-Fernandes, Xiang Fang, Adriana Paulucci-Holthauzen, Arpita Chatterjee, Hang L Zhang, Tohru Matsuura, Sanjeev Choudhary, Tetsuo Ashizawa, Arnulf H Koeppen, Patricia Maciel, Tapas K Hazra, Partha S Sarkar   +13 more
doaj   +1 more source

Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification

mBio, 2018
High-risk human papillomaviruses (HPVs) activate the ataxia telangiectasia mutated-dependent (ATM) DNA damage response as well as the ataxia telangiectasia mutated-dependent DNA-related (ATR) pathway in the absence of external DNA damaging agents for ...
Kavi Mehta, Laimonis Laimins
doaj   +1 more source

How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?

, 2023
Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a multitude of downstream pathways such as DNA damage repair ...
openaire   +2 more sources

Ataxia-telangiectasia mutated protein protects cardiac cells from stress by rewiring glucose metabolism [PDF]

European Heart Journal, 2020
Abstract Introduction Pressure overload-induced cardiac hypertrophy is associated with increased reactive oxygen species (ROS), inducing DNA damage and activating the protein kinase Ataxia-Telangiectasia Mutated (ATM).
Paolillo, Roberta, Boccella, Nicola, Caterino, Marianna, D'Apice, Stefania, Pezone, Antonio, Esposito, Giovanni, Ruoppolo, Margherita, Avvedimento, Vittorio Enrico, Perrino, Cinzia   +8 more
openaire   +2 more sources

En Guard! The Interactions between Adenoviruses and the DNA Damage Response

Viruses, 2020
Virus–host cell interactions include several skirmishes between the virus and its host, and the DNA damage response (DDR) network is one of their important battlegrounds.
Tamar Kleinberger
doaj   +1 more source

Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint [PDF]

Journal of Biological Chemistry, 2012
Dbf4/Cdc7 (Dbf4-dependent kinase (DDK)) is activated at the onset of S-phase, and its kinase activity is required for DNA replication initiation from each origin. We showed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replication initiation and to protect replication forks.
Alan Yueh-Luen, Lee, Takuya, Chiba, Lan N, Truong, An Ning, Cheng, Johnny, Do, Michael Jeffrey, Cho, Longchuan, Chen, Xiaohua, Wu   +7 more
openaire   +2 more sources

ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor

Biomolecules, 2015
The recognition, signalling and repair of DNA double strand breaks (DSB) involves the participation of a multitude of proteins and post-translational events that ensure maintenance of genome integrity. Amongst the proteins involved are several which when
Martin F. Lavin, Sergei Kozlov, Magtouf Gatei, Amanda W. Kijas   +3 more
doaj   +1 more source

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM [PDF]

Journal of Biological Chemistry, 2002
Chromosome aberrations, genomic instability, and cancer predisposition are hallmarks of a number of syndromes in which the defective genes recognize and/or repair DNA damage or are involved in some aspect of DNA processing. We report here direct interaction between BLM, mutated in Bloom's Syndrome (BS), and ATM, mutated is ataxia-telangiectasia, and we
Beamish, Heather, Kedar, Padmini, Kaneko, Hideo, Chen, Philip, Fukao, Toshiyuki, Peng, Cheng, Beresten, Sergei, Gueven, Nuri, Purdie, David, Lees-Miller, Susan, Ellis, Nathan, Kondo, Naomi, Lavin, Martin F.   +12 more
openaire   +5 more sources

The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis. [PDF]

PLoS ONE, 2012
BACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins.
Lin Zhao, Aihua Gu, Guixiang Ji, Peng Zou, Peng Zhao, Ailin Lu   +5 more
doaj   +1 more source