Results 11 to 20 of about 20,819 (199)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Residual Ataxia Telangiectasia Mutated Protein Function in Cells from Ataxia Telangiectasia Patients, with 5762ins137 and 7271T→G Mutations, Showing a Less Severe Phenotype [PDF]

Journal of Biological Chemistry, 2001
We have assessed several ataxia Telangiectasia mutated (ATM)-dependent functions in cells derived from ataxia telangiectasia patients, carrying either an ATM 5762ins137 splice site or a 7271T-->G missense mutation, with a less severe phenotype compared with the classical disorder.
G S, Stewart, J I, Last, T, Stankovic, N, Haites, A M, Kidd, P J, Byrd, A M, Taylor   +6 more
openaire   +2 more sources

Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage. [PDF]

PLoS ONE, 2018
All cellular processes, including those involved in normal cell metabolism to those responsible for cell proliferation or death, are finely controlled by cell signaling pathways, whose core proteins constitute the family of phosphatidylinositol 3-kinase ...
Raíssa Bernardes da Silva, Carlos Renato Machado, Aldo Rogelis Aquiles Rodrigues, André Luiz Pedrosa   +3 more
doaj   +1 more source

The versatile functions of ATM kinase

Biomedical Journal, 2014
Ataxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxia-telangiectasia, plays an essential role in the maintenance of genome stability.
Rebecca J Boohaker, Bo Xu
doaj   +1 more source

ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. [PDF]

PLoS ONE, 2010
Chromosome translocations induced by DNA damaging agents, such as ionizing radiation and certain chemotherapies, alter genetic information resulting in malignant transformation. Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a DNA
Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki, Shuki Mizutani, Roland Kanaar, Satoshi Tashiro   +10 more
doaj   +1 more source

Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair

Life Science Alliance, 2018
This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Noriko Hosoya, Masato Ono, Kiyoshi Miyagawa   +2 more
doaj   +1 more source

Dexamethasone Partially Rescues Ataxia Telangiectasia-mutated (ATM) Deficiency in Ataxia Telangiectasia by Promoting a Shortened Protein Variant Retaining Kinase Activity [PDF]

Journal of Biological Chemistry, 2012
Ataxia telangiectasia (AT) is a rare genetic disease, still incurable, resulting from biallelic mutations in the ataxia telangiectasia-mutated (ATM) gene. Recently, short term treatment with glucocorticoid analogues improved neurological symptoms characteristic of this syndrome. Nevertheless, the molecular mechanism involved in glucocorticoid action in
MENOTTA, MICHELE, BIAGIOTTI, SARA, BIANCHI, MARZIA, Chessa L, MAGNANI, MAURO   +4 more
openaire   +3 more sources

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Telangiectasia Mutated kinase [PDF]

Human Molecular Genetics, 2019
ABSTRACT Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the ataxin-1 protein. Recent genetic correlational studies have implicated DNA damage repair pathways in modifying the age at onset of disease symptoms in SCA1 and Huntington’s ...
Suart, Celeste, Perez, Alma M., Al-Ramahi, Ismael, Maiuri, Tamara, Botas, Juan, Truant, Ray   +5 more
openaire   +2 more sources

Progress towards a clinically-successful ATR inhibitor for cancer therapy

Current Research in Pharmacology and Drug Discovery, 2021
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated ...
Francis M. Barnieh, Paul M. Loadman, Robert A. Falconer   +2 more
doaj   +1 more source

Ataxia‐telangiectasia‐mutated protein expression with microsatellite instability in gastric cancer as prognostic marker [PDF]

International Journal of Cancer, 2013
The prognostic significance of ataxia‐telangiectasia‐mutated (ATM) expression in gastric cancer remains unclear. The functional loss of ATM gene exhibits a biologic correlation with microsatellite instability (MSI). In this study, we investigated the significance of ATM expression with MSI by evaluating gastric cancer patients who had underwent ...
Jin Won, Kim, Seock-Ah, Im, Min A, Kim, Hyun Jin, Cho, Dae Won, Lee, Kyung-Hun, Lee, Tae-Yong, Kim, Sae-Won, Han, Do-Youn, Oh, Hyuk-Joon, Lee, Tae-You, Kim, Han-Kwang, Yang, Woo Ho, Kim, Yung-Jue, Bang   +13 more
openaire   +2 more sources