Results 11 to 20 of about 20,763 (159)

Progress towards a clinically-successful ATR inhibitor for cancer therapy

Current Research in Pharmacology and Drug Discovery, 2021
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated ...
Francis M. Barnieh, Paul M. Loadman, Robert A. Falconer   +2 more
doaj   +1 more source

Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. [PDF]

PLoS Genetics, 2015
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an untreatable autosomal dominant neurodegenerative disease, and the most common such inherited ataxia worldwide.
Rui Gao, Yongping Liu, Anabela Silva-Fernandes, Xiang Fang, Adriana Paulucci-Holthauzen, Arpita Chatterjee, Hang L Zhang, Tohru Matsuura, Sanjeev Choudhary, Tetsuo Ashizawa, Arnulf H Koeppen, Patricia Maciel, Tapas K Hazra, Partha S Sarkar   +13 more
doaj   +1 more source

Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification

mBio, 2018
High-risk human papillomaviruses (HPVs) activate the ataxia telangiectasia mutated-dependent (ATM) DNA damage response as well as the ataxia telangiectasia mutated-dependent DNA-related (ATR) pathway in the absence of external DNA damaging agents for ...
Kavi Mehta, Laimonis Laimins
doaj   +1 more source

En Guard! The Interactions between Adenoviruses and the DNA Damage Response

Viruses, 2020
Virus–host cell interactions include several skirmishes between the virus and its host, and the DNA damage response (DDR) network is one of their important battlegrounds.
Tamar Kleinberger
doaj   +1 more source

ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor

Biomolecules, 2015
The recognition, signalling and repair of DNA double strand breaks (DSB) involves the participation of a multitude of proteins and post-translational events that ensure maintenance of genome integrity. Amongst the proteins involved are several which when
Martin F. Lavin, Sergei Kozlov, Magtouf Gatei, Amanda W. Kijas   +3 more
doaj   +1 more source

The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis. [PDF]

PLoS ONE, 2012
BACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins.
Lin Zhao, Aihua Gu, Guixiang Ji, Peng Zou, Peng Zhao, Ailin Lu   +5 more
doaj   +1 more source

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

Membranes, 2015
Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In
Maristella De Cicco, Munirah S. Abd Rahim, Sonja A. Dames   +2 more
doaj   +1 more source

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

eLife, 2022
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink   +16 more
doaj   +1 more source

Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle

Viruses, 2017
The Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt’s lymphoma, Hodgkin’s lymphoma, a subset of gastric carcinomas, and almost all ...
Pok Man Hau, Sai Wah Tsao
doaj   +1 more source

Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis

Chinese Medical Journal, 2015
Background: Caffeine suppresses ataxia telangiectasia and Rad3 related and ataxia telangiectasia mutated (ATM) activities; ATM is the major kinase for DNA damage detection.
Zhe-Wei Zhang, Jing Xiao, Wei Luo, Bo-Han Wang, Ji-Min Chen   +4 more
doaj   +1 more source