Results 31 to 40 of about 1,665,599 (197)
mBio, 2018 High-risk human papillomaviruses (HPVs) activate the ataxia telangiectasia mutated-dependent (ATM) DNA damage response as well as the ataxia telangiectasia mutated-dependent DNA-related (ATR) pathway in the absence of external DNA damaging agents for ...
Kavi Mehta, Laimonis Laimins
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How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
, 2023 Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a multitude of downstream pathways such as DNA damage repair ...
openaire +2 more sources
“A DNA Damage Response (DDR) –independent Role for the Ataxia-Telangiectasia Mutated (ATM) Gene Product" [PDF]
, 2010 Ataxia-Telangiectasia (A-T) is a recessive hereditary syndrome characterized by cerebellar degeneration, telangiectasia, precocious aging, immunodeficiency, cancer predisposition and insulin-resistant diabetes.
Palazzo, Luca
core +1 more source
En Guard! The Interactions between Adenoviruses and the DNA Damage Response
Viruses, 2020 Virus–host cell interactions include several skirmishes between the virus and its host, and the DNA damage response (DDR) network is one of their important battlegrounds.
Tamar Kleinberger
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Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint [PDF]
Journal of Biological Chemistry, 2012 Dbf4/Cdc7 (Dbf4-dependent kinase (DDK)) is activated at the onset of S-phase, and its kinase activity is required for DNA replication initiation from each origin. We showed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replication initiation and to protect replication forks.
Alan Yueh-Luen, Lee +7 more
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ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor
Biomolecules, 2015 The recognition, signalling and repair of DNA double strand breaks (DSB) involves the participation of a multitude of proteins and post-translational events that ensure maintenance of genome integrity. Amongst the proteins involved are several which when
Martin F. Lavin +3 more
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The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis. [PDF]
PLoS ONE, 2012 BACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins.
Lin Zhao +5 more
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Membranes, 2015 Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In
Maristella De Cicco +2 more
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eLife, 2022 A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting +16 more
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Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle
Viruses, 2017 The Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt’s lymphoma, Hodgkin’s lymphoma, a subset of gastric carcinomas, and almost all ...
Pok Man Hau, Sai Wah Tsao
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