PLoS ONE, 2013 Ataxia telangiectasia mutated kinase (ATM) is a cell cycle checkpoint protein activated in response to DNA damage. We recently reported that ATM plays a protective role in myocardial remodeling following β-adrenergic receptor stimulation.
Cerrone R Foster +5 more
semanticscholar +1 more source
Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle
Viruses, 2017 The Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt’s lymphoma, Hodgkin’s lymphoma, a subset of gastric carcinomas, and almost all ...
Pok Man Hau, Sai Wah Tsao
doaj +1 more source
The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations [PDF]
DNA Repair, 2019 The ataxia telangiectasia-mutated and Rad3-related (ATR) serine/threonine kinase plays a central role in the repair of replication-associated DNA damage, the maintenance of S and G2/M-phase genomic stability, and the promotion of faithful mitotic chromosomal segregation.
Jie Chen +7 more
openaire +2 more sources
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling [PDF]
, 2007 Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling.
A Kramer +42 more
core +4 more sources
Chinese Medical Journal, 2015 Background: Caffeine suppresses ataxia telangiectasia and Rad3 related and ataxia telangiectasia mutated (ATM) activities; ATM is the major kinase for DNA damage detection.
Zhe-Wei Zhang +4 more
doaj +1 more source
Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. [PDF]
PLoS ONE, 2013 Although structurally and biochemically similar to the cellular prion (PrP(C)), doppel (Dpl) is unique in its biological functions. There are no reports about any neurodegenerative diseases induced by Dpl.
Kefeng Qin +6 more
doaj +1 more source
A novel pathogenic variant in an Iranian Ataxia telangiectasia family revealed by next-generation sequencing followed by in silico analysis [PDF]
, 2017 Ataxia telangiectasia (A-T) is a neurodegenerative autosomal recessive disorder with the main characteristics of progressive cerebellar degeneration, sensitivity to ionizing radiation, immunodeficiency, telangiectasia, premature aging, recurrent ...
Alipour, Paria. +6 more
core +1 more source
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]
, 2012 Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Austin, Caroline +10 more
core +3 more sources
Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice
Cell Reports, 2012 Ataxia telangiectasia mutated (ATM) protein kinase activation by DNA double-strand breaks (DSBs) requires the Mre11-Rad50-NBS1 (MRN) complex, whereas ATM interactor (ATMIN) protein is required for ATM signaling induced by changes in chromatin structure ...
Tianyi Zhang +6 more
doaj +1 more source
514 ATAXIA TELANGIECTASIA MUTATED PROTEIN MODULATES GLUCOSE AND LIPID METABOLISM IN THE HEART
European Heart Journal Supplements, 2022 Abstract Background Ataxia Telangiectasia Mutated (ATM) protein kinase is the major sensor of DNA damage response (DDR) and oxidative stress, variously implicated in cellular metabolism. Previous studies on ATM functions in the heart have produced conflicting results.
Paolillo, Roberta +10 more
openaire +2 more sources