Results 271 to 280 of about 406,746 (290)
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How ATR turns on: TopBP1 goes on ATRIP with ATR.
Genes & development, 2008In this issue of Genes & Development, Mordes and colleagues (pp. 1478-1489) reveal intriguing mechanistic insights into activation of the ATR (ATM and Rad3-related) kinase critical for DNA damage resistance. They identify conserved regulatory domains within ATR and its binding partner ATRIP (ATR-interacting protein), which are contacted by the ATR ...
Anna E, Burrows, Stephen J, Elledge
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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Science, 2007S. Matsuoka +13 more
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Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates
2018ATR inhibitors are a new class of anti-cancer compounds reaching early phase clinical trials. They are predicted to have anti-cancer activity as monotherapy, and in combination with DNA damaging chemotherapies and ionizing radiation. We outline the clinical trials in progress using the current clinical candidates VX-970 (M6620) and AZD6738, discuss ...
Magnus T. Dillon, Kevin J. Harrington
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Mouse models for ATR deficiency
DNA Repair, 2009ATM and ATR orchestrate overlapping DNA damage responses in reply to different forms of DNA strand discontinuities. But, knockout mouse models suggest that ATR is essential for viability in contrast to ATM. Recently, more sophisticated mouse models have been published including a conditional ATR-knockdown system and by modelling the human ATR-Seckel ...
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ATR Applications in Military Missions
2007 IEEE Symposium on Computational Intelligence in Security and Defense Applications, 2007While there has been a nominal effort to develop automatic target recognition (ATR) technologies for military systems for the last couple of decades, there have been relatively few significant breakthroughs. At the same time, the evolution of some of our missions has made it more desirable to achieve solutions from this technology to meet some of the ...
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Journal of Slavic linguistics, 2007
The feature [ATR] is usually used exclusively for the description of vowels. In this article, it is argued that phonotactic constraints in Polish indicate that [ATR] may be a useful dimension in the description of consonants. Under this assumption we are able to offer a straightforward and phonetically motivated account of the discussed phonotactic ...
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The feature [ATR] is usually used exclusively for the description of vowels. In this article, it is argued that phonotactic constraints in Polish indicate that [ATR] may be a useful dimension in the description of consonants. Under this assumption we are able to offer a straightforward and phonetically motivated account of the discussed phonotactic ...
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First International Conference on Spoken Language Processing (ICSLP 1990), 1990
Terumasa Ehara +2 more
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Terumasa Ehara +2 more
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An extending ATR-CHK1 circuitry: the replication stress response and beyond.
Current Opinion in Genetics and Development, 2021A. Simoneau, L. Zou
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