Results 71 to 80 of about 406,746 (290)

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

Genes & Development, 2000
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency results in a severe proliferation defect and death in embryonic stem (ES) cells ...
Qinghua Liu, Saritha Guntuku, X. Cui, S. Matsuoka, D. Cortez, K. Tamai, G. Luo, Sandra Carattini-Rivera, F. Demayo, A. Bradley, L. Donehower, S. Elledge   +11 more
semanticscholar   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Segond's fracture: a biomechanical cadaveric study using navigation [PDF]

, 2017
Background Segond’s fracture is a well-recognised radiological sign of an anterior cruciate ligament (ACL) tear. While previous studies evaluated the role of the anterolateral ligament (ALL) and complex injuries on rotational stability of the knee ...
A Ferretti, A Ferretti, A. Ferretti, A. Redler, AA Amis, AB Goldman, AD Pearle, AL Dodds, B Sonnery-Cottet, CP Helito, D. Lupariello, Daniele Mazza, E Monaco, E. Monaco, EM Parsons, GW Woods, GY El-Khoury, JC Hughston, JP Vincent, M Daggett, M. Guzzini, MI Kennedy, R. Lanzetti, S Caterine, S Claes, S Claes, T Bonanzinga, W Muller   +27 more
core   +1 more source

Engineering Intelligent Graphene Oxide‐Cellulose Membranes: Suppressing Thermal Runaway for a Safer Aqueous Zinc‐Ion Batteries

Advanced Functional Materials, EarlyView.
A novel thermos‐responsive hydroxypropyl cellulose/graphene oxide (HPC/GO) composite membrane is fabricated for reversible temperature‐gated ion transport in aqueous zinc‐ion batteries. Enabled by LCST‐driven structural transition, unimpeded ion diffusion at room temperature delivers high capacity, while elevated temperature suppresses transport; full ...
Xueli Bi, Kou Yang, Shushen Zheng, Juncheng Wang, Meng Li, Zhenzhen Wu, Yulin Zhong, Daria V. Andreeva, Kostya S. Novoselov, Shanqing Zhang   +9 more
wiley   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop.

Molecules and Cells, 2019
R loops arising during transcription induce genomic instability, but how cells respond to the R loop-associated genomic stress is still poorly understood. Here, we show that cells harboring high levels of R loops rely on the ATR kinase for survival.
Dominick A. Matos, Jiamin Zhang, O. Jian, Hai Dang Nguyen, Marie-Michelle Genois, L. Zou   +5 more
semanticscholar   +1 more source

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The 50,000 origins that replicate the human genome are selected from an excess of licensed origins. Firing licensed origins that would otherwise be passively replicated is a simple mechanism to recover DNA replication between stalled ...
T. Moiseeva, Yandong Yin, Michael J. Calderon, Chenao Qian, Sandy Schamus-Haynes, Norie Sugitani, Hatice U. Osmanbeyoglu, E. Rothenberg, Simon C Watkins, C. Bakkenist   +9 more
semanticscholar   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

ETAA1 ensures proper chromosome segregation: A matter of S phase or mitosis? [PDF]

, 2019
ETAA1 activates the master checkpoint kinase ATR. Bass and Cortez (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810058) recently reported an intra-mitotic function of ETAA1 that safeguards chromosome stability.
Achuthankutty, Bass, Bass, Feng, Haahr, Kabeche, Lee, Marina Alejandra González Besteiro, Miosge, Saldivar, Saldivar, Vanesa Gottifredi, Zhou   +12 more
core   +1 more source