Results 31 to 40 of about 21,299 (243)

Popular Initiative as an Instrument of Migration Policy in Switzerland

Studia Iuridica Lublinensia, 2020
The main aim of this article was to present the popular initiatives in Switzerland concerning migration. The initiatives were presented in chronological order and analysed from historical and current perspectives, starting from 1968 with the initiative ...
Magdalena Perkowska
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo

Malaria Journal, 2022
Background Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-saving intervention for severe malaria in remote settings in Africa. Recognition of danger signs indicative of severe malaria is critical for prompt and appropriate case
Jean Okitawutshu, Aita Signorell, Jean-Claude Kalenga, Eric Mukomena, Giulia Delvento, Christian Burri, Fatou Mwaluke, Valentina Buj, Moulaye Sangare, Sylvie Luketa, Nina Brunner, Tristan Lee, Manuel Hetzel, Christian Lengeler, Antoinette Tshefu   +14 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A National, Semantic-Driven, Three-Pillar Strategy to Enable Health Data Secondary Usage Interoperability for Research Within the Swiss Personalized Health Network: Methodological Study

JMIR Medical Informatics, 2021
BackgroundInteroperability is a well-known challenge in medical informatics. Current trends in interoperability have moved from a data model technocentric approach to sustainable semantics, formal descriptive languages, and processes.
Christophe Gaudet-Blavignac, Jean Louis Raisaro, Vasundra Touré, Sabine Österle, Katrin Crameri, Christian Lovis   +5 more
doaj   +1 more source

The Swiss Human Rights Due Diligence Legislation: Between Law and Politics [PDF]

, 2021
On 29 November 2020, Swiss citizens voted on a popular constitutional initiative, known as the Swiss Responsible Business Initiative. The vote was triggered by an initiative signed by more than the required 100,000 Swiss citizens who used their ...
Kaufmann, Christine, Bueno, Nicolas; https://orcid.org/   +1 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Human and financial resource needs for universal access to WHO-PEN interventions for diabetes and hypertension care in Eswatini: results from a time-and-motion and bottom-up costing study

Human Resources for Health
Background Eswatini faces persistent challenges in providing care for diabetes and hypertension, exacerbated by a shortage of healthcare workers. The implementation of WHO-PEN interventions aimed to address these issues, yet their effects on healthcare ...
Harsh Vivek Harkare, Brianna Osetinsky, Ntombifuthi Ginindza, Bongekile Thobekile Cindzi, Nomfundo Mncina, Babatunde Akomolafe, Lisa-Rufaro Marowa, Nyasatu Ntshalintshali, Fabrizio Tediosi   +8 more
doaj   +1 more source

Diagnosis and management of chronic obstructive pulmonary disease: the swiss guidelines. Official guidelines of the Swiss Respiratory Society [PDF]

, 2013
The new Swiss Chronic Obstructive Pulmonary Disease (COPD) Guidelines are based on a previous version, which was published 10 years ago. The Swiss Respiratory Society felt the need to update the previous document due to new knowledge and novel ...
Brutsche, M, Steurer-Stey, C., Russi, E W, Kuhn, M., Kuhn, M, Rochat, T., Rochat, T, Karrer, W, Frey, Manuel, Brutsche, M., Quadri, F., Stolz, D., Eich, C, Quadri, F, Stolz, D, Russi, E. W., Fitting, J.W., Russi, E.W., Geiser, T, Nicod, L., Eich, C., Fitting, J. W., Steurer-Stey, C, Geiser, T., Frey, M, Frey, M., Karrer, W., Fitting, J W, Nicod, L   +28 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source