Results 41 to 50 of about 21,299 (243)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Efficacy of partial spraying of SumiShield, Fludora Fusion and Actellic against wild populations of Anopheles gambiae s.l. in experimental huts in Tiassalé, Côte d'Ivoire

Scientific Reports, 2023
From August 2020 to June 2021, we assessed the efficacy of SumiShield 50WG (clothianidin), Fludora Fusion 56.25WP-SB (mixture of clothianidin and deltamethrin) and Actellic 300CS (pirimiphos-methyl) in experimental huts when partially sprayed against ...
Joseph Chabi, Aklilu Seyoum, Constant V. A. Edi, Bernard Loukou Kouassi, Yemane Yihdego, Richard Oxborough, Constant G. N. Gbalegba, Ben Johns, Sameer Desale, Seth R. Irish, John E. Gimnig, Jenny S. Carlson, Melissa Yoshimizu, Jennifer S. Armistead, Allison Belemvire, Lilia Gerberg, Kristen George, Matthew Kirby   +17 more
doaj   +1 more source

The application of popular initiative in the Swiss Confederation [PDF]

, 2013
Instytucje demokracji bezpośredniej są stosowane w Konfederacji Szwajcarskiej na skalę nieporównywalną z jakimkolwiek innym państwem. Sama inicjatywa ludowa wykorzystywana jest co najmniej kilka razy do roku przez różnorodne grupy interesu i przez ...
Bednarz, Hanna
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Quantifying the impact of interventions against Plasmodium vivax: A model for country-specific use

Epidemics
In order to evaluate the impact of various intervention strategies on Plasmodium vivax dynamics in low endemicity settings without significant seasonal pattern, we introduce a simple mathematical model that can be easily adapted to reported case numbers ...
C. Champagne, M. Gerhards, J.T. Lana, A. Le Menach, E. Pothin   +4 more
doaj   +1 more source

Molecular monitoring of the diversity of human pathogenic malaria species in blood donations on Bioko Island, Equatorial Guinea

Malaria Journal, 2019
Background Malaria can be transmitted by blood transfusion from human to human and it is responsible for the majority of transfusion-transmitted infectious diseases worldwide.
Tobias Schindler, Tamy Robaina, Julian Sax, Jose Raso Bieri, Maximilian Mpina, Linda Gondwe, Ludmila Acuche, Guillermo Garcia, Carlos Cortes, Carl Maas, Claudia Daubenberger   +10 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden

BMC Infectious Diseases
Background Testing and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective treatment on burden and transmission via field studies
Flavia Camponovo, Aurélie Jeandron, Laura A Skrip, Monica Golumbeanu, Clara Champagne, Tasmin L Symons, Mark Connell, Peter W Gething, Theodoor Visser, Arnaud Le Menach, Justin M Cohen, Emilie Pothin   +11 more
doaj   +1 more source

Schoolchildren as Agents of Change towards Antimicrobial Resistance

Medical Sciences Forum, 2023
Schoolchildren are in their formative years, and therefore at an ideal stage in their lives to take in knowledge and best practices that will guide their future behavior.
Michael Mosha, Erick Venant, Baltazari Stanley, Fatuma Denis, Dorinegrace Mushi, Eva Ombaka, Karin Wiedenmayer   +6 more
doaj   +1 more source

Evaluation of existing and desired antimicrobial stewardship activities and strategies in Swiss hospitals

, 2017
Antimicrobial stewardship (AMS) is an important component in the fight against antimicrobial resistance. Currently, few hospitals have an ongoing institutional AMS programme.
Swiss Medical Weekly, Julia Bielicki, Michael Osthoff, Andreas F. Widmer   +3 more
core   +1 more source